| Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs. | |
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MedLine Citation:
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PMID: 22260163 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT Recently triptolide (TPL) has been proved to have the capacity of inhibiting the proliferation of multiple myeloma (MM) cells, as well as leukemic cells in vitro. In the present study, we found a synergistic effect when TPL was added to dexamethasone to induce apoptosis in MM.1S cells. This combination induced significantly higher proportion of apoptotic cells compared with those treated with each drug separately. TPL downregulated the expression of miR142-5p and miR181a which have been shown to inhibit glucocorticoid receptor (GR) expression. MicroRNA mimics and inhibitors inhibited or enhanced the synergistic effect between TPL and dexamethasone in inducing apoptosis in MM.1S cells, suggesting an important role of miR142-5p and miR181a in GR regulation by TPL. The in vitro proapoptotic effect of TPL associated with dexamethasone brings new clue for further clinical investigation for treatment of MM patients with TPL. |
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Authors:
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Xin Huang; Min Yang; Jie Jin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Leukemia & lymphoma Volume: - ISSN: 1029-2403 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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