| Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells. | |
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MedLine Citation:
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PMID: 20154595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Triptolide, a diterpenoid triepoxide derived from the Chinese herb Tripterygium wilfordii, exerts an antitumor effect in KB cancer cells through the induction of apoptosis. In this study, we show that triptolide possesses an anticancer effect on drug-sensitive parental KB cells and multidrug-resistant KB-7D and KB-tax cells that overexpress multidrug resistance protein and MDR, respectively. Our data revealed that triptolide decreases the expression of multidrug resistance protein and MDR in both KB-7D and KB-tax cells. It also induces apoptosis in these multidrug-resistant cancer cells by activating caspase-3, and decreasing Mcl-1 and XIAP. Triptolide not only inhibits tumor growth but also induces apoptosis of these drug-resistant cancer cells in xenograft mouse models. Moreover, we also show that triptolide combined with 5-fluorouracil could be an alternative strategy for chemotherapy enhancement. These results indicate the therapeutic value of triptolide on multidrug-resistant cells, and when combined with 5-fluorouracil for the enhancement of cancer therapy. |
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Authors:
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Yuan-Wu Chen; Gu-Jiun Lin; Yi-Ping Chuang; Wei-Tso Chia; Dueng-Yuan Hueng; Chih-Kung Lin; Shin Nieh; Huey-Kang Sytwu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anti-cancer drugs Volume: 21 ISSN: 1473-5741 ISO Abbreviation: Anticancer Drugs Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100823 Medline TA: Anticancer Drugs Country: England |
Other Details:
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Languages: eng Pagination: 502-13 Citation Subset: IM |
Affiliation:
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Graduate Institute of Medical Sciences, National Defense Medical Center, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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pharmacology* Apoptosis / drug effects Body Weight / drug effects Caspase 3 / metabolism Diterpenes / pharmacology* Down-Regulation / drug effects Drug Resistance, Neoplasm / drug effects Drug Screening Assays, Antitumor Drug Synergism Epoxy Compounds / pharmacology Fluorouracil / pharmacology* Humans KB Cells P-Glycoprotein / metabolism Phenanthrenes / pharmacology* Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors, metabolism X-Linked Inhibitor of Apoptosis Protein / antagonists & inhibitors, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Diterpenes; 0/Epoxy Compounds; 0/P-Glycoprotein; 0/Phenanthrenes; 0/Proto-Oncogene Proteins c-bcl-2; 0/X-Linked Inhibitor of Apoptosis Protein; 0/myeloid cell leukemia sequence 1 protein; 38748-32-2/triptolide; 51-21-8/Fluorouracil; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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