Document Detail


Triptans in pregnancy.
MedLine Citation:
PMID:  18223456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The triptans are a class of tryptamine-based drugs indicated for in the treatment of migraine headaches. The triptans act as serotonin (5-hydroxytriptamine) (5-HT) agonists by binding to various serotonin receptors, causing vasoconstriction and neuronal inhibition to alleviate migraines. There are 7 types of triptans currently available on the U.S. market: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan. The objective of this study was to examine the use and effects of triptans in pregnancy. Although three of the triptans have pregnancy registries maintained by the manufacturer, triptan use in pregnancy has not been extensively studied. Information on the use of sumatriptan during pregnancy is relatively more abundant, because it has been on the market longer than the other triptans and may also have a higher percentage of the market share. There are no data to suggest teratogenicity for any of the triptans, although preterm birth rates appear to be elevated.
Authors:
Offie P Soldin; Julia Dahlin; Daniel M O'Mara
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  30     ISSN:  0163-4356     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-05-08     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA. os35@georgetown.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Humans
Migraine Disorders / drug therapy*
Pregnancy
Pregnancy Complications / drug therapy*
Pregnancy Outcome
Prenatal Exposure Delayed Effects*
Serotonin Receptor Agonists / adverse effects*
Tryptamines / adverse effects*
Grant Support
ID/Acronym/Agency:
M01 RR020359/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Receptor Agonists; 0/Tryptamines
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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