| Triptans in pregnancy. | |
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MedLine Citation:
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PMID: 18223456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The triptans are a class of tryptamine-based drugs indicated for in the treatment of migraine headaches. The triptans act as serotonin (5-hydroxytriptamine) (5-HT) agonists by binding to various serotonin receptors, causing vasoconstriction and neuronal inhibition to alleviate migraines. There are 7 types of triptans currently available on the U.S. market: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan and zolmitriptan. The objective of this study was to examine the use and effects of triptans in pregnancy. Although three of the triptans have pregnancy registries maintained by the manufacturer, triptan use in pregnancy has not been extensively studied. Information on the use of sumatriptan during pregnancy is relatively more abundant, because it has been on the market longer than the other triptans and may also have a higher percentage of the market share. There are no data to suggest teratogenicity for any of the triptans, although preterm birth rates appear to be elevated. |
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Authors:
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Offie P Soldin; Julia Dahlin; Daniel M O'Mara |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 30 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-05-08 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: United States |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA. os35@georgetown.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Humans Migraine Disorders / drug therapy* Pregnancy Pregnancy Complications / drug therapy* Pregnancy Outcome Prenatal Exposure Delayed Effects* Serotonin Receptor Agonists / adverse effects* Tryptamines / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR020359/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Receptor Agonists; 0/Tryptamines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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