Document Detail

Triploidy: antenatal sonographic features with post-mortem correlation.
MedLine Citation:
PMID:  9885016     Owner:  NLM     Status:  MEDLINE    
A retrospective study was performed comparing the antenatal ultrasound (US) scan features with post-mortem findings in 20 triploid fetuses surviving beyond the first trimester. US scans showed a range of abnormalities including oligohydramnios (60 per cent of cases), intra-uterine growth retardation (IUGR, 55 per cent), central nervous system (CNS) abnormalities (45 per cent), and placental abnormalities (55 per cent). There were obstetric complications in 30 per cent of cases. Post-mortem examinations confirmed these findings but also demonstrated additional anomalies including facial dysmorphism, limb abnormalities (syndactyly, talips equinovarus and thigh muscle hypertrophy), and anomalies of cardio-vascular, respiratory and genito-urinary system. The placenta was normal in 16 per cent of cases, enlarged with cystic change in 47 per cent, small in 32 per cent and infarcted in 5 per cent of cases. Various factors including oligohydramnios, abnormal fetal position, less sophisticated equipment in mid-1980s and relative inexperience of early observers contributed to the reduced sensitivity of US scans in diagnosis of various defects. However, triploidy should be considered in all cases showing early second-trimester IUGR with or without oligohydramnios, a major CNS abnormality and/or an enlarged placenta with or without changes of partial hydatidiform mole. As triploidy is associated with increased obstetric complications, fetal karyotyping should be offered to confirm the diagnosis so that appropriate obstetric intervention can be instituted.
T K Mittal; G M Vujanić; B M Morrissey; A Jones
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  18     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1253-62     Citation Subset:  IM    
Department of Diagnostic Radiology, University Hospital of Wales, Cardiff, U.K.
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MeSH Terms
Abnormalities, Multiple / ultrasonography*
Chromosome Aberrations / diagnosis
Chromosome Disorders
Fetal Diseases / ultrasonography*
Fetal Growth Retardation / ultrasonography
Gestational Age
Nervous System Malformations / ultrasonography
Oligohydramnios / ultrasonography
Placenta Diseases / ultrasonography
Pregnancy Complications / ultrasonography*
Retrospective Studies
Ultrasonography, Prenatal*

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