| Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption. | |
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MedLine Citation:
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PMID: 14565468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the effective recognition of C x G interruption in homopurine-homopyrimidine duplex DNA, we examined triplex-forming ability and sequence-selectivity of a triplex-forming oligonucleotide (TFO) involving of 2'-O, 4'-C-methylene bridged nucleic acid with 1-isoquinolone base analogue. We found that the modified TFO formed stable triplex with high binding affinity and sequence-selectivity. |
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Authors:
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Hidetaka Torigoe; Yoshiyuki Hari; Satoshi Obika; Takeshi Imanishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 22 ISSN: 1525-7770 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2003 May-Aug |
Date Detail:
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Created Date: 2003-10-20 Completed Date: 2003-12-11 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 1571-3 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan. htorigoe@ch.kagu.tus.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Base Pairing* Cytosine DNA / chemistry* Guanine Hydrocarbons Hydrogen Bonding Isoquinolines* Methane / analogs & derivatives* Nucleic Acid Conformation* Oligodeoxyribonucleotides / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Hydrocarbons; 0/Isoquinolines; 0/Oligodeoxyribonucleotides; 119-65-3/isoquinoline; 2465-56-7/carbene; 71-30-7/Cytosine; 73-40-5/Guanine; 74-82-8/Methane; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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