Document Detail

Triplet ultrasound growth parameters.
MedLine Citation:
PMID:  16507943     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To create ultrasound growth curves for normal growth of fetal triplets using statistical methodology that properly accounts for similarities of growth of fetuses within a mother as well as repeated measurements over time for each fetus. METHODS: In this longitudinal study, all triplet pregnancies managed at a single tertiary center from 1992-2004 were reviewed. Fetuses with major anomalies, prior selective reduction, or fetal demise were excluded. Data from early and late gestation in which there were fewer than 30 fetal measurements available for analysis were excluded. We used multilevel models to account for variation in growth within a single fetus over time, variations in growth between multiple fetuses within a single mother, and variations in fetal growth between mothers. Medians (50th), 10th, and 90th percentiles were estimated by the creation of multiple quadratic growth models from bootstrap samples adapting a previously published method to compute prediction intervals. Estimated fetal weight was derived from Hadlock's formula. RESULTS: One hundred fifty triplet pregnancies were identified. Twenty-seven pregnancies were excluded for the following reasons: missing records (23), fetal demise (3), and fetal anomaly (1). The study group consisted of 123 pregnancies. The gestational age range was restricted to 14-34 weeks. Figures and tables were developed showing medians, 10th and 90th percentiles for estimated fetal weight, femur length, biparietal diameter, abdominal circumference, and head circumference. CONCLUSION: Growth curves for triplet pregnancies were derived. These may be useful for identification of abnormal growth in triplet fetuses. LEVEL OF EVIDENCE: III.
Neeta L Vora; Robin Ruthazer; Michael House; David Chelmow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  107     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-01     Completed Date:  2007-11-20     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  694-700     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Tufts-New England Medical Center, Boston, Massachusetts 02116, USA.
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MeSH Terms
Fetal Development / physiology*
Longitudinal Studies
Reference Values
Triplets / physiology*
Ultrasonography, Prenatal*

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