Document Detail

Triple therapy of Helicobacter pylori infection in peptic ulcer. A 12-month follow-up study of 93 patients.
MedLine Citation:
PMID:  1455197     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to evaluate the success of triple therapy in peptic ulcer patients and ulcer relapses. One hundred and one consecutive Helicobacter pylori-positive peptic ulcer patients were assigned to an open trial with 2 weeks of treatment with colloidal bismuth subcitrate, amoxicillin, and metronidazole. At the 6-week follow-up only 1 duodenal ulcer was unhealed of 57 active ulcers, and H. pylori was found to be eradicated in 84% of the 100 subjects. The sensitivity to metronidazole was determined from 71 pretreatment strains of H. pylori. Eradication of H. pylori succeeded in 89% of the patients with metronidazole-susceptible strains and in 61% of patients with metronidazole-resistant strains (p < 0.03). All 16 patients in whom the treatment failed to eradicate the organism had metronidazole-resistant strains after treatment. The ulcer relapse rate was low. At the 12-month follow-up of 93 patients only 1 of the 84 H. pylori-negative patients (including 4 patients after new successful therapy) had relapsing ulcers (2 asymptomatic episodes), and 1 had H. pylori reinfection, whereas 3 of the 9 bacteria-positive patients relapsed (p = 0.002); at the 2-year control 2 more patients had ulcer relapses. The eradication of H. pylori infection clearly prevents relapses of peptide ulcer, but the success of triple therapy depends on the frequency of pretreatment metronidazole-resistant H. pylori strains.
K Seppälä; M Färkkilä; H Nuutinen; K Hakala; H Väänänen; H Rautelin; T U Kosunen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  27     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  973-6     Citation Subset:  IM    
Second Dept. of Medicine, Helsinki University Central Hospital, Finland.
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MeSH Terms
Administration, Oral
Aged, 80 and over
Amoxicillin / administration & dosage*
Anti-Ulcer Agents / administration & dosage*
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Endoscopy, Gastrointestinal
Follow-Up Studies
Helicobacter Infections / drug therapy*
Helicobacter pylori / drug effects*
Metronidazole / administration & dosage*
Middle Aged
Organometallic Compounds / administration & dosage*
Peptic Ulcer / drug therapy*
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Organometallic Compounds; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 57644-54-9/bismuth tripotassium dicitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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