| Triple therapy of Helicobacter pylori infection in peptic ulcer. A 12-month follow-up study of 93 patients. | |
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MedLine Citation:
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PMID: 1455197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was undertaken to evaluate the success of triple therapy in peptic ulcer patients and ulcer relapses. One hundred and one consecutive Helicobacter pylori-positive peptic ulcer patients were assigned to an open trial with 2 weeks of treatment with colloidal bismuth subcitrate, amoxicillin, and metronidazole. At the 6-week follow-up only 1 duodenal ulcer was unhealed of 57 active ulcers, and H. pylori was found to be eradicated in 84% of the 100 subjects. The sensitivity to metronidazole was determined from 71 pretreatment strains of H. pylori. Eradication of H. pylori succeeded in 89% of the patients with metronidazole-susceptible strains and in 61% of patients with metronidazole-resistant strains (p < 0.03). All 16 patients in whom the treatment failed to eradicate the organism had metronidazole-resistant strains after treatment. The ulcer relapse rate was low. At the 12-month follow-up of 93 patients only 1 of the 84 H. pylori-negative patients (including 4 patients after new successful therapy) had relapsing ulcers (2 asymptomatic episodes), and 1 had H. pylori reinfection, whereas 3 of the 9 bacteria-positive patients relapsed (p = 0.002); at the 2-year control 2 more patients had ulcer relapses. The eradication of H. pylori infection clearly prevents relapses of peptide ulcer, but the success of triple therapy depends on the frequency of pretreatment metronidazole-resistant H. pylori strains. |
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Authors:
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K Seppälä; M Färkkilä; H Nuutinen; K Hakala; H Väänänen; H Rautelin; T U Kosunen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 27 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-01-06 Completed Date: 1993-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 973-6 Citation Subset: IM |
Affiliation:
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Second Dept. of Medicine, Helsinki University Central Hospital, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Aged, 80 and over Amoxicillin / administration & dosage* Anti-Ulcer Agents / administration & dosage* Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Endoscopy, Gastrointestinal Female Follow-Up Studies Helicobacter Infections / drug therapy* Helicobacter pylori / drug effects* Humans Male Metronidazole / administration & dosage* Middle Aged Organometallic Compounds / administration & dosage* Peptic Ulcer / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Organometallic Compounds; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 57644-54-9/bismuth tripotassium dicitrate |
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