Document Detail

Triple test for prenatal detection of Edwards syndrome (trisomy 18).
MedLine Citation:
PMID:  8624894     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE(S): To demonstrate the limitation of complete reliance on computer generated interpretations and to highlight the need for understanding of pregnancy-related biochemistry when offering prenatal screening. METHODS: Four cases of cytogenetically confirmed trisomy 18 pregnancies are presented. All four cases underwent prenatal screening (Triple Test-AFP, uE3, t beta-hCG) at midgestation and risk assessment by the alpha algorithm. RESULTS: All four cases of trisomy 18 were assessed as being at low risk for DS and/or open NTD. Although marker levels were not consistent with either of these clinical situations, they were indicative of a compromised pregnancy. Circulating levels of trophoblast-derived antigens (uE3, t beta-hCG) were depressed (< or = 0.5 MoM) in all four cases. Further investigations (ultrasonography, amniocentesis) confirmed a trisomy 18 fetus. CONCLUSIONS: Risk assessment by computer based algorithms relies on maternal factors and specific DS/NTD marker profiles. Aberrant marker profiles are not distinguished from normal. Therefore, it is essential that prenatal screening is offered only by those competent in pregnancy biochemistry and able to identify these abnormal situations.
M J Sinosich; B Cameron; R D Robertson; D M Saunders
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  22     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-06-21     Completed Date:  1996-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Royal North Shore Hospital, St Leonards, Australia.
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MeSH Terms
Biological Markers
Chromosomes, Human, Pair 18*
Diagnosis, Computer-Assisted*
Neural Tube Defects / diagnosis
Prenatal Diagnosis / methods*
Risk Assessment
Reg. No./Substance:
0/Biological Markers

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