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Triple-negative breast cancer: making the most of a misnomer.
MedLine Citation:
PMID:  22524573     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Triple-negative breast cancer (TNBC) is defined by its lack of (or minimal) estrogen receptor and progesterone receptor expression, together with the absence of human epidermal growth factor receptor 2 overexpression or gene amplification. It can be a particularly aggressive form of breast cancer, often characterized by early systemic relapse. This subtype, absent from traditional pathology classifications, has quietly crept into the oncologist's lexicon over the last decade and aroused considerable research interest. Based on tumor pathology, immunohistochemistry and gene profiling studies, TNBC is likely to represent a heterogeneous mix of breast cancer subtypes. This observation will have important implications for the selection of optimal therapies, which are yet to be defined. This article reviews recent insights in the classification and ontogeny of TNBC, current approaches to its management and promising therapeutic targets that are forming the basis for innovative early and late phase clinical trials.
Authors:
Nicole McCarthy; Gillian Mitchell; Michael Bilous; Nicholas Wilcken; Geoffrey J Lindeman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asia-Pacific journal of clinical oncology     Volume:  8     ISSN:  1743-7563     ISO Abbreviation:  Asia Pac J Clin Oncol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241430     Medline TA:  Asia Pac J Clin Oncol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  145-55     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Asia Pty Ltd.
Affiliation:
Wesley Medical Centre, Brisbane, Queensland Peter MacCallum Cancer Centre, Melbourne, Victoria Healthscope Pathology, Norwest Private Hospital, Sydney, New South Wales Westmead Hospital, University of Sydney, Sydney, New South Wales The Walter and Eliza Hall Institute of Medical Research Royal Melbourne Hospital University of Melbourne, Melbourne, Victoria, Australia.
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