Document Detail


Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas.
MedLine Citation:
PMID:  19409639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: To test the effect of BIBF 1120, a novel small molecule inhibitor of multiple angiogenic receptor tyrosine kinases, on the hypoxia and radiation response of tumours.
MATERIALS AND METHODS: Poorly differentiated human squamous cell carcinoma FaDu growing in nude mice was treated with BIBF 1120 and investigated by functional histology. To test the effect of BIBF 1120 on the radiobiological hypoxic fraction (rHF), the number and intrinsic radiation sensitivity of tumour stem cells and the outcome after fractionated irradiation, a series of local tumour control assays were performed.
RESULTS: BIBF 1120 significantly reduced the vessel area, vessel area with a perfusion signal and tumour growth rate but did not affect tumour hypoxia or the number and intrinsic radiation sensitivity of tumour stem cells. Concurrent BIBF 1120 had no effect on local tumour control after fractionated irradiation.
CONCLUSION: Triple angiokinase inhibition resulted in a clear-cut decrease of angiogenesis, vessel area with a perfusion signal and tumour growth but did not change tumour hypoxia or radiation response of tumour stem cells. Further experiments into mechanisms of interaction between anti-angiogenic strategies and irradiation appear to be necessary to better define and exploit the potential of this strategy to improve local tumour control after fractionated radiotherapy.
Authors:
Daniel Zips; Katja Le; Ala Yaromina; Annegret Dörfler; Wolfgang Eicheler; Xuanjing Zhou; Peter Geyer; Frank Hilberg; Michael Baumann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-04
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  92     ISSN:  1879-0887     ISO Abbreviation:  Radiother Oncol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-15     Completed Date:  2010-01-12     Revised Date:  2012-12-24    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  405-10     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, OncoRay Centre for Radiation Research, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse, Germany. daniel.zips@uniklinikum-dresden.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Squamous Cell / drug therapy*,  pathology,  radiotherapy*
Cell Hypoxia / drug effects,  radiation effects
Cell Survival / drug effects,  radiation effects
Disease Models, Animal
Dose Fractionation
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Female
Immunohistochemistry
Indoles / pharmacology*
Laryngeal Neoplasms / drug therapy*,  pathology,  radiotherapy*
Male
Mice
Mice, Nude
Neoplasm Transplantation
Neovascularization, Pathologic / prevention & control*
Probability
Radiation Tolerance / drug effects
Random Allocation
Reference Values
Chemical
Reg. No./Substance:
0/Indoles; G6HRD2P839/nintedanib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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