| Triple agent immunosuppressive therapy in Vogt-Koyanagi-Harada syndrome. | |
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MedLine Citation:
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PMID: 17162603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe the role of triple agent immunosuppression in severe recalcitrant cases of Vogt-Koyanagi-Harada syndrome. MATERIALS AND METHODS: Retrospective chart review of five cases of Vogt-Koyanagi-Harada syndrome. RESULTS: All cases were treated with oral prednisolone, azathioprine, and cyclosporine in combination, and rapid remission was observed in all patients. The synergistic effect of the triple agent immunosuppressives helped in preventing recurrences. Prolonged treatment with steroid sparing immunosuppressives in severe and recalcitrant cases of Vogt-Koyanagi-Harada syndrome maintained disease remission. CONCLUSION: Severe cases of Vogt-Koyanagi-Harada syndrome can be treated with early use of high-dose triple agent immunosuppressives. |
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Authors:
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Mamta Agarwal; Sudha K Ganesh; Jyotirmay Biswas |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 14 ISSN: 0927-3948 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2007-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: England |
Other Details:
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Languages: eng Pagination: 333-9 Citation Subset: IM |
Affiliation:
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Medical Research Foundation, Sankara Nethralaya, Chennai, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Azathioprine / therapeutic use* Cyclosporine / therapeutic use* Drug Therapy, Combination Female Follow-Up Studies Fundus Oculi Glucocorticoids / therapeutic use* Humans Immunosuppressive Agents / therapeutic use* Middle Aged Ophthalmoscopy Prednisolone / therapeutic use* Remission Induction / methods Retrospective Studies Uveomeningoencephalitic Syndrome / drug therapy*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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