Document Detail


Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?
MedLine Citation:
PMID:  22022923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cannabinoids comprise three major classes of substances, including compounds derived from the cannabis plant (e.g. Δ(9) -tetrahydrocannabinol and the chemically related substances CP55940 and HU210), endogenously formed (e.g. anandamide) and synthetic compounds (e.g. WIN55212-2). Beyond their psychotropic effects, cannabinoids have complex effects on blood pressure, including biphasic changes of Δ(9) -tetrahydrocannabinol and WIN55212-2 and an even triphasic effect of anandamide. The differing pattern of blood pressure changes displayed by the three types of compounds is not really surprising since, although they share an agonistic effect at cannabinoid CB(1) and CB(2) receptors, some compounds have additional effects. In particular, anandamide is known for its pleiotropic effects, and there is overwhelming evidence that anandamide influences blood pressure via (i) CB(1) receptors, (ii) TRPV1 receptors, (iii) endothelial cannabinoid receptors and (iv) degradation products. This review is dedicated to the description of the effects of externally added cannabinoids on cardiovascular parameters in vivo. First, the cardiovascular effects of cannabinoids in anaesthetized animals will be highlighted since most data have been generated in experiments of that type. The text will follow the three phases of anandamide on blood pressure, and we will check to which extent cardiovascular changes elicited by other cannabinoids show overlap with those effects or differ. The second part will be dedicated to the cardiovascular effects of the cannabinoids in conscious animals. In the third part, cardiovascular effects in humans will be discussed, and similarities and differences with respect to the data from animals will be examined.
Authors:
Barbara Malinowska; Marta Baranowska-Kuczko; Eberhard Schlicker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of pharmacology     Volume:  165     ISSN:  1476-5381     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2073-88     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
Affiliation:
Zakład Fizjologii i Patofizjologii Doświadczalnej, Uniwersytet Medyczny w Białymstoku, ul. Mickiewicza 2A, Białystok, Poland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acids / pharmacology
Blood Pressure / drug effects*,  physiology
Cannabinoids / chemistry,  pharmacology*
Cardiovascular Physiological Phenomena / drug effects
Cardiovascular System / drug effects
Endocannabinoids
Humans
Models, Cardiovascular
Polyunsaturated Alkamides / pharmacology
Receptor, Cannabinoid, CB1 / drug effects
Receptor, Cannabinoid, CB2 / drug effects
Species Specificity
TRPV Cation Channels / drug effects
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Cannabinoids; 0/Endocannabinoids; 0/Polyunsaturated Alkamides; 0/Receptor, Cannabinoid, CB1; 0/Receptor, Cannabinoid, CB2; 0/TRPV Cation Channels; 0/TRPV1 receptor; 94421-68-8/anandamide
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