Document Detail


Trinucleotide repeats are prevalent among cancer-related genes.
MedLine Citation:
PMID:  18054813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trinucleotide repeats (TNRs) have been primarily connected to neurologic and neuromuscular diseases, with few specific TNRs linked with various tumors. Here we conduct a genome-wide analysis and show that TNRs are five times more prevalent in cancer-related human genes. Interestingly, we also find that cancer-related genes are significantly longer than other genes. Our results suggest that genes containing TNRs are more prone to mutagenesis. The database of TNR genes can be used as a list of candidate cancer-related genes.
Authors:
Yael Haberman; Ninette Amariglio; Gideon Rechavi; Eli Eisenberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-04
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  24     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-28     Completed Date:  2008-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Affiliation:
Department of Pediatric Hemato-Oncology, the Edmond and Lily Safra Children's Hospital and Cancer Research Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Genes, Neoplasm*
Genome / genetics
Humans
Trinucleotide Repeats / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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