Document Detail

Trimethoprim-sulfamethoxazole therapy for infective endocarditis.
MedLine Citation:
PMID:  7029718     Owner:  NLM     Status:  MEDLINE    
A man with stenosis of the aortic valve acquired endocarditis after abdominal surgery. Klebsiella pneumoniae and Acinetobacter calcoaceticus were cultured from his blood. The blood cultures remained positive despite intravenous gentamicin and cephalothin to which the organisms were sensitive in vitro. Ultimately, the blood was sterilized by a combination of gentamicin and trimethoprim-sulfamethoxazole taken orally. The course of the patient was complicated by cardiac arrest and pericardial tamponade caused by a valve ring abscess and a dissecting mycotic aneurysm of the coronary sinus of Valsalva. Aortic valve replacement and right coronary artery bypass were performed. A prolonged course of trimethoprim-sulfamethoxazole was given postoperatively, and the patient has had no evidence of recurrent infection after five years. Trimethoprim-sulfamethoxazole, in combination with other antibiotics, has been successfully used to treat other patients with bacterial endocarditis and thus may be an alternative for patients in whom conventional therapy has failed.
R C Noble; R M Cooper; A L Jarvis; P L Caples; E P Todd
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  74     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1299-303     Citation Subset:  AIM; IM    
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MeSH Terms
Acinetobacter Infections / drug therapy
Aneurysm, Infected / surgery
Drug Combinations
Endocarditis, Bacterial / drug therapy*
Klebsiella Infections / drug therapy
Klebsiella pneumoniae
Middle Aged
Sulfamethoxazole / therapeutic use*
Trimethoprim / therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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