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Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice.
MedLine Citation:
PMID:  25064584     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Obesity is a significant risk factor for the development of cardiovascular disease. Inhibiting fatty acid oxidation has emerged as a novel approach for the treatment of ischemic heart disease. Our aim was to determine whether pharmacologic inhibition of 3-ketoacyl-coenzyme A thiolase (3-KAT), which catalyzes the final step of fatty acid oxidation, could improve obesity-induced cardiomyopathy. A 3-week treatment with the 3-KAT inhibitor trimetazidine prevented obesity-induced reduction in both systolic and diastolic function. Therefore, targeting cardiac fatty acid oxidation may be a novel therapeutic approach to alleviate the growing burden of obesity-related cardiomyopathy.
Authors:
John R Ussher; Natasha Fillmore; Wendy Keung; Jun Mori; Donna L Beker; Cory S Wagg; Jagdip S Jaswal; Gary D Lopaschuk
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Publication Detail:
Type:  Journal Article     Date:  2014-04-29
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  30     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-07-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  940-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
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