Document Detail


Trimetazidine: a new concept in the treatment of angina. Comparison with propranolol in patients with stable angina. Trimetazidine European Multicenter Study Group.
MedLine Citation:
PMID:  8198938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Trimetazidine has a direct anti-ischaemic effect on the myocardium without altering the rate x pressure product or coronary blood flow. 2. The effects of trimetazidine (20 mg three times daily) were compared with those of propranolol (40 mg three times daily) in a double-blind parallel group multicentre study in 149 men with stable angina. 3. Reproducibility of exercise performance was verified during a 3 week run-in placebo washout period. All patients had > 1 mm ST-depression on exercise test. 4. After 3 months, similar anti-anginal efficacy was observed between the trimetazidine (n = 71) and propranolol (n = 78) groups. No significant differences were observed between trimetazidine and propranolol as regards anginal attack rate per week (mean difference P-TMZ: 2; 95% CI: -4.4, 0.5) and exercise duration (mean difference P-TMZ: 0 s; 95% CI: -33, 34) or time to 1 mm ST segment depression (mean difference P-TMZ: 13 s; 95% CI: -24, 51). Heart rate and rate x pressure product at rest and at peak exercise remained unchanged in the trimetazidine group but significantly decreased with propranolol (P < 0.001 in all cases). With both drugs there was a trend to decreased ischaemic episodes in the 46% patients who experienced ambulatory ischaemia on Holter monitoring. Six patients stopped trimetazidine and 12 propranolol. Of these, five in each group were withdrawn because of deterioration in cardiovascular status. 5. The results suggest that trimetazidine and propranolol at the doses studied have similar efficacy in patients with stable angina pectoris.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J M Detry; P Sellier; S Pennaforte; D Cokkinos; H Dargie; P Mathes
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  37     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-07     Completed Date:  1994-07-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279-88     Citation Subset:  IM    
Affiliation:
Saint-Luc University Hospital, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / drug therapy*
Blood Pressure / drug effects
Double-Blind Method
Electrocardiography / drug effects
Exercise Tolerance
Heart Rate / drug effects
Humans
Male
Middle Aged
Propranolol / administration & dosage,  pharmacology,  therapeutic use*
Reproducibility of Results
Trimetazidine / administration & dosage,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
5011-34-7/Trimetazidine; 525-66-6/Propranolol
Comments/Corrections

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