| Trimestral variations of C-reactive protein, interleukin-6 and tumour necrosis factor-{alpha} are similarly associated with survival in haemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 20846939 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: The impact of intra-individual changes of inflammatory markers [other than C-reactive protein (CRP)] on mortality in haemodialysis (HD) patients is unknown. We therefore studied survival in relation to trimestral variations of CRP, interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α). METHODS: In 201 prevalent HD patients from the Mapping of Inflammatory Markers in Chronic Kidney Disease cohort, serum CRP, IL-6 and TNF-α were measured 3 months apart and survival was assessed during follow-up. Based on fluctuations along tertiles of distribution, four patterns were defined for each inflammatory marker: stable low, decrease, increase and stable high. Hazard ratios were calculated by the Cox proportional hazard model, and Pearson's test was used to correlate changes. CRP analyses were replicated in 472 incident HD patients from the Netherlands Cooperative Study on the Adequacy of Dialysis. RESULTS: Patients with persistently elevated CRP values had the worst mortality in crude [HR 2.98 (95% CI 1.71-5.20)] and adjusted [2.79 (1.58-4.94)] Cox models, together with those who increased in their CRP levels [crude 3.27 (1.91-5.60); adjusted 3.13 (1.79-5.45)]. Similar survival patterns were observed for IL-6 and TNF-α variation categories. Correlations among these changes were, however, not strong. In the replication cohort, individuals with persistently elevated CRP values also showed the highest mortality risk [crude 3.38 (2.31-4.94); adjusted 2.33 (1.58-3.45)]. CONCLUSIONS: Trimestral variations of TNF-α, IL-6, and CRP are similarly associated with survival in HD patients. The agreement between changes of these biomarkers was low, suggesting that different pathways may trigger each of these markers. |
| | |
Authors:
|
Christiaan L Meuwese; Sunna Snaedal; Nynke Halbesma; Peter Stenvinkel; Friedo W Dekker; Abdul R Qureshi; Peter Barany; Olof Heimburger; Bengt Lindholm; Raymond T Krediet; Els W Boeschoten; Juan J Carrero |
Related Documents
:
|
2471249 - Interleukin-6 (il-6) and acute phase proteins in the disease course of patients with sy... 8156489 - Antiphospholipid syndrome associated with immunotherapy for patients with melanoma. 8844339 - Relation between macrophage and t helper-2 lymphocyte functions in human neoplasms: neo... 12900819 - C-reactive protein, lipoprotein(a), homocysteine, and male sex contribute to carotid at... 17216679 - Color and duplex doppler sonography to detect sacroiliitis and spinal inflammation in a... 12811429 - Relationship between the tumor necrosis factor alpha polymorphism and the serum c-react... 2984599 - Postoperative prophylactic anticonvulsant therapy in cerebral gliomas. 19969139 - Tissue diagnosis of new lung nodules in patients with a known malignancy. 8214699 - Excitatory effects and electroencephalographic correlation of etomidate, thiopental, me... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-15 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
|
Languages: eng Pagination: 1313-8 Citation Subset: IM |
Affiliation:
|
Correspondence and offprint requests to: Juan Jesús Carrero; E-mail: juan.jesus.carrero@ki.se. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kidney and liver cysts in autosomal dominant polycystic kidney disease.
Next Document: Glomerular diseases and transplantation: similarities in pathogenetic mechanisms and treatment optio...