| Trimester- and method-specific reference intervals for thyroid tests in pregnant Chinese women: methodology, euthyroid definition and iodine status can influence the setting of reference intervals. | |
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MedLine Citation:
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PMID: 21044115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The importance of diagnosis and treatment of thyroid dysfunction during pregnancy has been widely recognized. We therefore established trimester- and method-specific reference intervals for thyroid testing in pregnant women according to the NACB recommended criteria. Several factors can affect the setting of reference intervals, in particular manufacturer's methodology, euthyroid definition and iodine status. DESIGN: Cross-sectional dataset analysis. SUBJECTS: Five hundred and five normal pregnant women at different stages of gestation were rigorously selected for setting reference intervals. All were healthy, iodine sufficient, euthyroid and negative for both serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb). MEASUREMENTS: Thyrotrophin (TSH), total and free thyroxine (TT4 and FT4), total and free triiodothyronine (TT3 and FT3) and anti-TPOAb and anti-TgAb were measured using the Bayer ADVIA Centaur system. Iodine content in drinking water, salt and urine was determined by national standard methods. The 2·5th and 97·5th percentiles were calculated as the reference intervals for thyroid hormone levels during each trimester. RESULTS: All participants had long-term consumption of iodized salt and median urinary iodine of 150-200 μg/l during each three trimester. The reference intervals for the first, second and third trimesters were, respectively, TSH 0·03-4·51, 0·05-4·50 and 0·47-4·54 mIU/l and FT4 11·8-21·0, 10·6-17·6 and 9·2-16·7 pmol/l. The manufacturer's method, euthyroid definition and iodine status may influence TSH and FT4 reference intervals. Alterations in thyroid hormone concentrations during pregnancy differed at different stage of gestation and to those of a nonpregnant state. CONCLUSIONS: The trimester- and method-based reference intervals for thyroid tests during pregnancy are clinically appropriate. Some variables should be controlled when establishing reference intervals. |
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Authors:
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Yu-Qin Yan; Zuo-Liang Dong; Ling Dong; Feng-Rui Wang; Xue-Ming Yang; Xing-Yi Jin; Lai-Xiang Lin; Yi-Na Sun; Zu-Pei Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical endocrinology Volume: 74 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-07 Completed Date: 2011-05-09 Revised Date: 2011-09-19 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 262-9 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Institute of Endocrinology, and Key Laboratory of Hormone and Development of China Ministry of Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China. yanyuqin2005@yahoo.com.cn |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cross-Sectional Studies Female Humans Iodine / blood* Pregnancy Pregnancy Trimesters / blood Reference Values Thyroid Gland / metabolism* Thyrotropin / blood Thyroxine / blood Triiodothyronine / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin |
| Comments/Corrections | |
Comment In:
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Clin Endocrinol (Oxf). 2011 Sep;75(3):406-7
[PMID:
21521330
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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