| Trimazosin in chronic congestive heart failure: improved left ventricular function at rest and during exercise. | |
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MedLine Citation:
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PMID: 6139004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hemodynamic effects of the oral vasodilator trimazosin were evaluated in patients with chronic congestive heart failure (CHF), initially over a 72-hour period (13 patients), and after 3 months of maintenance therapy (seven patients). During the initial evaluation, cardiac index and stroke work index increased an average of 24% and 37% respectively, and pulmonary capillary wedge pressure decreased by 26%. These beneficial hemodynamic effects were maintained during supine bicycle exercise. After 3 months of maintenance therapy, cardiac index (+30%) and stroke work index (+38%) remained elevated, and pulmonary capillary wedge pressure was lower (-38%). Improved hemodynamics during exercise were also seen after maintenance therapy. Withdrawal of trimazosin was associated with deterioration in hemodynamics and left ventricular function. Thus trimazosin has the potential to cause sustained improvement in left ventricular function, both at rest and during exercise, in patients with chronic CHF. |
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Authors:
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T A Ports; K Chatterjee; P Wilkinson; D Avakian; W W Parmley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 106 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1036-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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administration & dosage Aged Cardiac Output / drug effects* Chronic Disease Exercise Test Female Heart Failure / drug therapy*, physiopathology Humans Long-Term Care Male Middle Aged Piperazines / administration & dosage* Pulmonary Wedge Pressure / drug effects Rest Stroke Volume / drug effects* Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Piperazines; 0/Vasodilator Agents; 35795-16-5/trimazosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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