Document Detail


Trilostane but not prostaglandin F2alpha (PGF2alpha) or cortisol aborts 90-day-pregnant lutectomized sheep.
MedLine Citation:
PMID:  10560611     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ewes were lutectomized and treatments were started 72 h later. Pregnant ewes were treated with vehicle; prostaglandin F2alpha (PGF2alpha); cortisol (C); trilostane (TR), a 3beta-hydroxy-steroid dehydrogenase inhibitor; PGF2alpha + C; TR + PGF2alpha; TR + C, or TR + PGF2 + C. TR, TR + PGF2alpha, TR + C, and TR + PGF2alpha + C aborted (P < or = 0.05) all ewes receiving TR. One ewe treated with PGF2alpha aborted (P > or = 0.05). The average time to abortion of TR-treated ewes was 50.8 h (P < or = 0.05) after initiation of treatments. All aborted ewes had retained placentas (P < or = 0.05) except one ewe in the TR + PGF2alpha, treatment group. TR was given every 12 h starting at 72 h postlutectomy until 96 h postlutectomy. TR reduced (P < or = 0.05) progesterone. Estradiol-17beta was increased (P < or = 0.05) 2 h after the first two TR treatments and declined 2 h later and was followed by a sustained increase (P < or = 0.05) in estradiol-17beta, which was coincident with the onset of abortions. Estradiol-17beta was increased (P < or = 0.05) by PGF2alpha but did not decrease (P > or = 0.05) placental secretion of progesterone. It is concluded that TR but not PGF2alpha is an abortifacient in 90-day-pregnant lutectomized ewes and that abortion occurs only when there is a decrease in circulating progesterone and an increase in circulating estradiol-17beta.
Authors:
Y S Weems; D L Vincent; C Lemme; C W Weems
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Prostaglandins & other lipid mediators     Volume:  58     ISSN:  1098-8823     ISO Abbreviation:  Prostaglandins Other Lipid Mediat.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808648     Medline TA:  Prostaglandins Other Lipid Mediat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-86     Citation Subset:  IM    
Affiliation:
Department of Animal Science, University of Hawaii, Honolulu 96822, USA.
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxysteroid Dehydrogenases / antagonists & inhibitors
Abortifacient Agents, Steroidal / pharmacology*
Abortion, Induced / veterinary
Abortion, Veterinary*
Animals
Corpus Luteum / physiology,  surgery
Dihydrotestosterone / analogs & derivatives*,  pharmacology
Dinoprost / pharmacology
Enzyme Inhibitors / pharmacology
Estradiol / blood
Female
Hydrocortisone / pharmacology
Organ Size
Placenta / physiology
Pregnancy
Pregnancy, Animal / drug effects*
Progesterone / metabolism
Sheep
Time Factors
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Steroidal; 0/Enzyme Inhibitors; 13647-35-3/trilostane; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 521-18-6/Dihydrotestosterone; 551-11-1/Dinoprost; 57-83-0/Progesterone; EC 1.1.-/3-Hydroxysteroid Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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