| Trilostane but not prostaglandin F2alpha (PGF2alpha) or cortisol aborts 90-day-pregnant lutectomized sheep. | |
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MedLine Citation:
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PMID: 10560611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ewes were lutectomized and treatments were started 72 h later. Pregnant ewes were treated with vehicle; prostaglandin F2alpha (PGF2alpha); cortisol (C); trilostane (TR), a 3beta-hydroxy-steroid dehydrogenase inhibitor; PGF2alpha + C; TR + PGF2alpha; TR + C, or TR + PGF2 + C. TR, TR + PGF2alpha, TR + C, and TR + PGF2alpha + C aborted (P < or = 0.05) all ewes receiving TR. One ewe treated with PGF2alpha aborted (P > or = 0.05). The average time to abortion of TR-treated ewes was 50.8 h (P < or = 0.05) after initiation of treatments. All aborted ewes had retained placentas (P < or = 0.05) except one ewe in the TR + PGF2alpha, treatment group. TR was given every 12 h starting at 72 h postlutectomy until 96 h postlutectomy. TR reduced (P < or = 0.05) progesterone. Estradiol-17beta was increased (P < or = 0.05) 2 h after the first two TR treatments and declined 2 h later and was followed by a sustained increase (P < or = 0.05) in estradiol-17beta, which was coincident with the onset of abortions. Estradiol-17beta was increased (P < or = 0.05) by PGF2alpha but did not decrease (P > or = 0.05) placental secretion of progesterone. It is concluded that TR but not PGF2alpha is an abortifacient in 90-day-pregnant lutectomized ewes and that abortion occurs only when there is a decrease in circulating progesterone and an increase in circulating estradiol-17beta. |
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Authors:
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Y S Weems; D L Vincent; C Lemme; C W Weems |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Prostaglandins & other lipid mediators Volume: 58 ISSN: 1098-8823 ISO Abbreviation: Prostaglandins Other Lipid Mediat. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-30 Completed Date: 1999-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9808648 Medline TA: Prostaglandins Other Lipid Mediat Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 77-86 Citation Subset: IM |
Affiliation:
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Department of Animal Science, University of Hawaii, Honolulu 96822, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxysteroid Dehydrogenases
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antagonists & inhibitors Abortifacient Agents, Steroidal / pharmacology* Abortion, Induced / veterinary Abortion, Veterinary* Animals Corpus Luteum / physiology, surgery Dihydrotestosterone / analogs & derivatives*, pharmacology Dinoprost / pharmacology Enzyme Inhibitors / pharmacology Estradiol / blood Female Hydrocortisone / pharmacology Organ Size Placenta / physiology Pregnancy Pregnancy, Animal / drug effects* Progesterone / metabolism Sheep Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Steroidal; 0/Enzyme Inhibitors; 13647-35-3/trilostane; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 521-18-6/Dihydrotestosterone; 551-11-1/Dinoprost; 57-83-0/Progesterone; EC 1.1.-/3-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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