Document Detail

Trilineage phenotypic compromise in acute leukemia.
MedLine Citation:
PMID:  10439377     Owner:  NLM     Status:  MEDLINE    
The expression of three lineage specific antigens in the leukemic blasts is extremely infrequent. We here report a case of triphenotypic acute leukemia with involvement of the myeloid and B and T lineages. The morphology of the blasts showed promyelocytic features with agranular cytoplasm, suggesting a M3-variant of AML. The blasts were positive for myeloperoxidase PAS and Sudan Black. Immunophenotype and cytogenetics did not confirm M3-AML diagnosis, showing a trilineage compromise (myeloid and T and B lymphoid markers) and the cytogenetic alterations +8 and +11, respectively. This report highlights the importance of correlating the results of multiple diagnostic methods in order to establish a correct diagnosis of mixed lineage acute leukemias, and allows evaluation of the prognostic importance of this subgroup of patients.
M P Scolnik; M F Palacios; F R Ramirez; R Tur; M V Castuma; M M Bracco
Related Documents :
24707417 - Dramatic intracerebral hemorrhagic presentations of reversible cerebral vasoconstrictio...
6930197 - Acute lymphoblastic leukemia following hodgkin's disease.
3469227 - Fusarium as a pathogen. a case report of fusarium sepsis and review of the literature.
9614517 - Necrotising fasciitis as a complication of botulinum toxin injection.
9236907 - Dermatofibrosarcoma protuberans of the upper lip: an overview and a case report.
982217 - Schistosomiasis and carcinoma of the bladder in zambia.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  34     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-21     Completed Date:  1999-09-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
IIHEMA, Academia Nacional De Medicina De Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Separation
Fatal Outcome
Flow Cytometry
Leukemia, Myeloid, Acute / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clonal analysis of B-cell leukemias and lymphomas using the polymerase chain reaction for the third ...
Next Document:  Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic l...