Document Detail


Trilineage phenotypic compromise in acute leukemia.
MedLine Citation:
PMID:  10439377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of three lineage specific antigens in the leukemic blasts is extremely infrequent. We here report a case of triphenotypic acute leukemia with involvement of the myeloid and B and T lineages. The morphology of the blasts showed promyelocytic features with agranular cytoplasm, suggesting a M3-variant of AML. The blasts were positive for myeloperoxidase PAS and Sudan Black. Immunophenotype and cytogenetics did not confirm M3-AML diagnosis, showing a trilineage compromise (myeloid and T and B lymphoid markers) and the cytogenetic alterations +8 and +11, respectively. This report highlights the importance of correlating the results of multiple diagnostic methods in order to establish a correct diagnosis of mixed lineage acute leukemias, and allows evaluation of the prognostic importance of this subgroup of patients.
Authors:
M P Scolnik; M F Palacios; F R Ramirez; R Tur; M V Castuma; M M Bracco
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  34     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-21     Completed Date:  1999-09-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
Affiliation:
IIHEMA, Academia Nacional De Medicina De Buenos Aires, Argentina. postmaster@anmra.sld.ar
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Separation
Fatal Outcome
Flow Cytometry
Humans
Leukemia, Myeloid, Acute / pathology*
Male
Phenotype

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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