Document Detail

Triiodothyronine (T3) and metabolic rate in adolescents with eating disorders: is there a correlation?
MedLine Citation:
PMID:  23221424     Owner:  NLM     Status:  Publisher    
Purpose: To examine the correlation between T3 and resting energy expenditure(REE) in adolescent patients with eating disorders (ED) to assess whether T3 can be used to predict metabolic rate suppression and recovery. Methods: A retrospective chart review was performed on patients with ED (Anorexia Nervosa [AN], Bulimia Nervosa [BN], and Eating Disorder NOS [EDNOS]), aged 11-22 years, who had T3 and REE measured within 1 month (n=38 AN, 32 BN/EDNOS). REE was measured by indirect calorimetry (IC) and represented as the percentage of expected REE (%EREE) predicted by the Harris-Benedict equation. Pearson correlation coefficients were calculated to examine the relationship between T3 and %EREE and how each correlates with anthropometric data, laboratory values, and diagnosis. Results: T3 was significantly correlated with %EREE in the AN group but not in the total population or BN/EDNOS group. In the total study population, T3 alone correlated significantly with weight, Body Mass Index (BMI), BMI percentile, %Ideal Body Weight (IBW), %Maximum Weight Lost (MWL), LH, and estradiol. In the AN group, T3 and %EREE both correlated with BMI, BMI percentile, LH, and estradiol; however, only T3 correlated with %IBW and %MWL. In the BN/EDNOS group, T3 correlated with BMI, BMI percentile, %IBW, and estradiol while %EREE correlated with none. Conclusion: In patients with AN, T3 correlated significantly with markers of malnutrition and %EREE and may serve as a surrogate measure when IC is unavailable. Following T3 during treatment of AN may assist clinicians in assessing metabolic suppression and recovery and help guide caloric prescriptions and goal weights.
Diana L Aschettino-Manevitz; Rollyn M Ornstein; Wendy Meyer Sterling; Nina Kohn; Martin Fisher
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-26
Journal Detail:
Title:  Eating and weight disorders : EWD     Volume:  -     ISSN:  1590-1262     ISO Abbreviation:  Eat Weight Disord     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9707113     Medline TA:  Eat Weight Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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