Document Detail

Trihalomethane exposures from municipal water supplies and selected congenital malformations.
MedLine Citation:
PMID:  12606885     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Concerns about potential health effects of trihalomethanes (THMs) have prompted investigations on whether infants whose mothers were periconceptionally exposed to drinking water containing THMs are at greater risk of congenital malformations. METHODS: We used two large case-control maternal interview studies that were conducted among California deliveries from 1987 through 1991. One study comprised 538 infants/fetuses with neural tube defects (NTDs) and 539 nonmalformed control infants. The second study included an additional 265 infants with NTDs, 207 infants with conotruncal heart defects, 409 infants with orofacial clefts, and 481 control infants. Expert personnel from municipal water companies estimated THM levels for a particular residence and specific periconceptional time period using quarterly monitoring measurements. Estimates were also made for four individual THM levels and for the total THM level. RESULTS: NTD risk in the first study was inversely associated with total THM exposure. Although the second study did not show the same inverse relationship for NTDs, there were no positive associations of NTDs or the other malformations with total THM as estimated from continuous models. Elevated risks were observed for the lowest category of exposure (1-24 ppb), but risks were either not substantially elevated or were imprecise for higher exposure levels. Thus no evidence was observed for an exposure-response relation. CONCLUSIONS: Our results do not provide a clear pattern of association between THM exposure and risks of specific congenital malformations. Imprecise exposure measures coupled with a lack of information about other possible sources of THM exposure may have caused associations to be underestimated.
Gary M Shaw; Dilrini Ranatunga; Thu Quach; Eric Neri; Adolfo Correa; Raymond R Neutra
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  14     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-27     Completed Date:  2003-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Oakland, CA 94606, USA.
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MeSH Terms
California / epidemiology
Case-Control Studies
Congenital Abnormalities / epidemiology*
Environmental Exposure / adverse effects
Infant, Newborn
Interviews as Topic
Maternal Exposure / adverse effects,  statistics & numerical data*
Pregnancy Outcome
Risk Factors
Trihalomethanes / adverse effects,  analysis*
Water Pollutants, Chemical / adverse effects,  analysis*
Water Supply*
Grant Support
U50/CCU913241/CC/CDC HHS
Reg. No./Substance:
0/Trihalomethanes; 0/Water Pollutants, Chemical

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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