| Triglycerides and small dense low density lipoprotein in the discrimination of coronary heart disease risk in South Asian populations. | |
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MedLine Citation:
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PMID: 19922937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Coronary heart disease (CHD) is exceptionally prevalent amongst globally dispersed migrant groups originating from the Indian subcontinent, but the contribution of dyslipidaemia to their increased risk remains poorly defined. METHODS: Fasting lipids and lipoproteins, apolipoproteins (Apo), low density lipoprotein (LDL) diameter and oxidised LDL were measured amongst rural Indians in India (n=294) and their migrant contemporaries in the UK (n=242). The performance of qualitative and quantitative measures of lipid metabolism were compared in the discrimination of WHO defined metabolic risk and raised Framingham CHD risk scores (>15%) using Receiver Operating Characteristic (ROC) curves. RESULTS: LDL diameter was correlated with triglycerides (R(2)=0.12, P<0.001) and with high density lipoprotein (HDL) cholesterol levels (R(2)=0.15, P<0.001) in both groups. Migrants had less small dense LDL (95% CI: 12.5-14.2%) vs. rural Indians (15.7-17.2, P<0.05). On ROC analysis, triglycerides were the only consistent discriminators of metabolic and CHD risk scores (all P< or =0.001). Apo B was also a strong indicator of raised CHD risk scores. Irrespective of site, individuals with raised triglycerides also had higher total cholesterol and Apo B, denser LDL, lower HDL and more oxidised LDL (all P< or =0.01). DISCUSSION: Fasting triglycerides reflect both qualitative and quantitative aspects of lipid metabolism, and are a comprehensive discriminator of CHD risk in this South Asian population. |
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Authors:
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J V Patel; M J Caslake; A Vyas; J K Cruickshank; D Prabhakaran; D Bhatnagar; K S Reddy; G Y H Lip; M I Mackness; E A Hughes; P N Durrington |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-13 |
Journal Detail:
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Title: Atherosclerosis Volume: 209 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 579-84 Citation Subset: IM |
Copyright Information:
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Crown Copyright 2009. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Clinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, UK. Jeetesh.Patel@swbh.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins B / blood Asian Continental Ancestry Group Cholesterol, HDL / blood Coronary Disease / blood, epidemiology* Female Great Britain / epidemiology Humans India / epidemiology, ethnology Lipoproteins, LDL / blood* Male Middle Aged ROC Curve Risk Factors Transients and Migrants Triglycerides / blood* |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/oxidized low density lipoprotein |
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