| Triglycerides and remnant particles as risk factors for coronary artery disease. | |
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MedLine Citation:
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PMID: 16510044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery disease (CAD) is the largest cause of morbidity and mortality in the world. A relationship between CAD and elevated levels of low-density lipoprotein cholesterol has been established. However, risk assessment limited to low-density lipoprotein fails to identify a significant portion of patients at risk for CAD. Remnant lipoproteins, derived from very low-density lipoprotein and chylomicrons, have been considered atherogenic. Recently, a simple and reliable immunoaffinity separation method for the isolation of remnant-like particles (RLP) has been developed. It has been shown that RLP cholesterol levels are significantly correlated with CAD, and thus cellular mechanisms have been determined by which RLP cholesterol causes progression of atherosclerosis. Measurement of RLP cholesterol is useful for the assessment of risk and the evaluation of therapy in patients at risk for CAD. |
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Authors:
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Takamitsu Nakamura; Kiyotaka Kugiyama |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current atherosclerosis reports Volume: 8 ISSN: 1523-3804 ISO Abbreviation: Curr Atheroscler Rep Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-02 Completed Date: 2006-05-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897685 Medline TA: Curr Atheroscler Rep Country: United States |
Other Details:
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Languages: eng Pagination: 107-10 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Nakakoma-gun, Yamanashi 409-3898, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cholesterol / blood* Coronary Disease / blood*, epidemiology, etiology Humans Incidence Lipoproteins / blood* Risk Factors Triglycerides / blood* World Health |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipoproteins; 0/Triglycerides; 0/remnant-like particle cholesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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