| Triglyceride-lowering effect of pitavastatin [corrected] in a rat model of postprandial lipemia. | |
| | |
MedLine Citation:
|
PMID: 12191589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The triglyceride-lowering effect of pitavastatin, a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, was investigated in a rat model of postprandial lipemia. Plasma triglyceride levels started to increase 4 h after the fat load, reached the maximum at 6 h and then gradually decreased. A single dose of pitavastatin (1 mg/kg) significantly suppressed chylomicron-triglyceride secretion into the lymph by 40% and delayed the elevation of plasma triglyceride. Pitavastatin at 1 mg/kg decreased the 6-h plasma triglyceride levels by 53% and at 0.5 mg/kg decreased the 0-12 h area under the curve (AUC) of triglyceride levels by 56%. Atorvastatin also caused decreases, but to a lesser extent. Pitavastatin, and atorvastatin to a lesser extent, reduced the activity of the intestinal microsomal triglyceride transfer protein (MTP) at 6 h. These results suggested that a single dose of pitavastatin lowered postprandial triglyceride levels in rats by decreasing chylomicron-triglyceride secretion, probably through a reduction of intestinal MTP activity and triglyceride droplet formation in the endoplasmic reticulum. |
| | |
Authors:
|
Taro Aoki; Yasunobu Yoshinaka; Hiroyuki Yamazaki; Hideo Suzuki; Taro Tamaki; Fumiyasu Sato; Masaki Kitahara; Yasushi Saito |
Related Documents
:
|
9649599 - Alpha-tocopherol concentrations in plasma but not in lipoproteins fluctuate during the ... 220359 - Changes in plasma very low density and low density lipoprotein content, composition, an... 178469 - Studies on the serum lipoprotein composition in 50-year-old men. a suggestion of chemic... 2022059 - In vivo effect of simvastatin on lipoprotein cholesteryl ester metabolism in normochole... 7426089 - Relationship between apolipoproteins and chemical components of lipoproteins in survivo... 10588949 - Apolipoprotein b overproduction by the perfused liver of the st. thomas' mixed hyperlip... 3059829 - Intracerebroventricular infusions of 3-ohb and insulin in a rat model of dietary obesity. 6735939 - Effect of energy intake on the postpartum interval in beef cows and the adequacy of the... 17643889 - N-6 and n-3 fatty acids ratio and vitamin e in porcine maternal diet influence the anti... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 444 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2002 May |
Date Detail:
|
Created Date: 2002-08-22 Completed Date: 2003-01-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 107-13 Citation Subset: IM |
Affiliation:
|
Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd., 2-17-43, Higashimurayama, Tokyo, 189-0022, Japan. t-oaki@kowa.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Chylomicrons / drug effects Hyperlipidemias / drug therapy* Male Postprandial Period Quinolines / therapeutic use* Rats Rats, Wistar Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Chylomicrons; 0/Quinolines; 0/Triglycerides; 147526-32-7/NK 104 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relaxation induced by milrinone and rolipram in human penile arteries and veins.
Next Document: Nicotine suppresses gastric wound repair via the inhibition of polyamine and K(+) channel expression...