Document Detail


Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review.
MedLine Citation:
PMID:  10812585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is increasing evidence that serum triglycerides are a significant and independent risk factor for CVD. The aim of this report is to review recent literature pertinent to the triglyceride-lowering effect of omega-3 long chain polyunsaturated fatty acids (LC-PUFA). Animal data are not considered because they are difficult to extrapolate to the human situation. A large body of evidence derived from epidemiological studies and clinical trials has consistently demonstrated that this effect is dose-dependent and can be achieved by diet. The smallest amount of omega-3 LC-PUFA needed to significantly lower serum triglycerides appears to be approximately 1 g/day as provided by a fish diet. Use of fish oil administering as little as 0.21 g EPA and 0.12 g DHA per day significantly lowered serum triglycerides in hyperlipidemics. In normolipidemics, a daily intake of 0.17 g EPA and 0.11 g DHA, given as a fish oil supplement, induced a non-significant reduction of 22%. These findings must be considered as preliminary and warrant further research. Intake of omega-3 LC-PUFA is frequently reported to modestly increase LDL cholesterol. However, in normo- or slightly hyperlipidemic individuals who received omega-3 LC-PUFA for 4 months or longer, changes of LDL cholesterol were not significantly different from a placebo group. Both EPA and DHA lower serum triglycerides, but they may have a differential effect on lipoproteins. Intake of omega-3 LC-PUFA in the amount mentioned above is safe.
Authors:
P Weber; D Raederstorff
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  10     ISSN:  0939-4753     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-06-20     Completed Date:  2000-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  28-37     Citation Subset:  IM    
Affiliation:
F. Hoffmann-La Roche Ltd., Vitamins and Fine Chemicals Division, Basel, Switzerland. peter.weber@roche.com
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MeSH Terms
Descriptor/Qualifier:
Cardiovascular Diseases / prevention & control*
Docosahexaenoic Acids / administration & dosage*
Eicosapentaenoic Acid / administration & dosage*
Fish Oils / administration & dosage
Humans
Hyperlipidemias / diet therapy*
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Fish Oils; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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