Document Detail


Triglyceride lipases alter fuel metabolism and mitochondrial gene expression.
MedLine Citation:
PMID:  19448696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acids derived from the hydrolysis of adipose tissue and skeletal muscle triacylglycerol (TG) are an important energy substrate at rest and during prolonged moderate-intensity exercise. Hormone sensitive lipase (HSL) was long considered to be the rate-limiting enzyme for adipocyte and skeletal muscle TG lipolysis. However, the understanding of TG lipolysis regulation was recently challenged by the finding that adipose TG lipase (ATGL) is the predominant TG lipase in adipose tissue and an important regulator of TG degradation in skeletal muscle. Thus, it is now proposed that ATGL and HSL regulate lipolysis in a serial manner, with ATGL cleaving the first fatty acid and HSL the second fatty acid of TG. Further to this biochemical evaluation, the generation and metabolic characterization of ATGL-/- and HSL-/- mice have revealed distinct phenotypes. ATGL-/- mice are obese, exhibit impaired thermogenesis, oxidize more carbohydrate, and die prematurely due to cardiac dysfunction. Studies in HSL-/- mice report defective beta-adrenergic stimulated lipolysis, protection against high-fat diet-induced obesity, and possible impairments in insulin secretion. This review outlines the current understanding of the cellular regulation of TG lipases, lipolytic regulation, and the functional implications of manipulating ATGL and HSL in vivo.
Authors:
Matthew J Watt
Related Documents :
15952896 - Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors.
7346056 - Fatty acid composition of mammary gland lipids of lactating and nonlactating buffaloes.
12833166 - Coenzyme q releases the inhibitory effect of free fatty acids on mitochondrial glycerop...
24024886 - Comparative developmental toxicity of new aromatic halogenated dbps in a chlorinated sa...
20456526 - Effects of hops (humulus lupulus l.) extract on volatile fatty acid production by rumen...
8189326 - Evaluation of reference ranges for fatty acids in serum.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  34     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  340-7     Citation Subset:  IM    
Affiliation:
Department of Physiology, Monash University, Clayton, Victoria, Australia. matthew.watt@med.monash.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Energy Metabolism / physiology*
Fatty Acids / metabolism
Gene Expression Regulation / physiology*
Humans
Lipase / metabolism*
Mice
Mitochondria / metabolism*
Muscle, Skeletal / metabolism
Rats
Chemical
Reg. No./Substance:
0/Fatty Acids; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Exercise training, energy metabolism, and heart failure.
Next Document:  Mitochondrial DNA shifting in older adults following resistance exercise training.