Document Detail

Triggers of acute coronary syndromes.
MedLine Citation:
PMID:  12024335     Owner:  NLM     Status:  MEDLINE    
Despite recent progress in prevention of coronary heart disease, approximately 50% of the deaths from coronary artery disease continue to occur out of hospital, and many major cardiac events occur in individuals not previously known to be at risk. These facts create the need to identify the acute causes of myocardial infarction (MI) and sudden death, which has led to a rapid growth in interest over the last 15 years in the field of triggering research. Since initial observations that the incidence of MI onset was time and activity dependent with circadian, circaseptan, and circannual variation, triggering of MI by heavy exertion, sexual activity, anger, mental stress, cocaine and marijuana use, and exposure to air pollution has been demonstrated. Study of the pathophysiological changes produced by these triggers may provide novel therapeutic and preventive targets by a more thorough understanding of vulnerable plaque disruption and coronary thrombosis.
Stephen J Servoss; James L Januzzi; James E Muller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  44     ISSN:  0033-0620     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-06-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-80     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2002, Elsevier Science (USA). All rights reserved.
Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA02114, USA.
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MeSH Terms
Angina, Unstable / etiology*,  prevention & control
Coronary Artery Disease / complications*,  physiopathology
Coronary Thrombosis / etiology
Death, Sudden, Cardiac / etiology*,  prevention & control
Myocardial Infarction / etiology*,  prevention & control
Physical Exertion
Risk Factors
Rupture, Spontaneous / etiology
Substance-Related Disorders / complications
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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