| Triggering with GnRH agonist in oocyte-donation cycles: oestradiol monitoring is not necessary during ovarian stimulation. | |
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MedLine Citation:
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PMID: 22196891 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This prospective observational study evaluated the efficacy and safety of oocyte-donation cycles triggered with a gonadotrophin-releasing hormone (GnRH) agonist without monitoring oestradiol concentrations during ovarian stimulation. A total of 97 oocyte donors received recombinant FSH (150-225/day) and GnRH antagonists (0.25mg/day). Oocyte maturation was triggered with 0.2mg triptorelin s.c. Donors aged 25.4±4.1years were stimulated for 8.8±0.9days and underwent 2.9±0.5 (2-4) ultrasound assessments. Total FSH dose was 1703.4±304.7IU, antagonists were administered for 4.3±1.0days, 14.7±8.8 oocytes were retrieved and there were no cases of ovarian hyperstimulation syndrome. Recipients (n=123) aged 40.3±3.4years received 10.9±4.3 oocytes, 88.7% of which were metaphase II. Intracytoplasmic sperm injection fertilization rate was 79% and 2.18±0.6 (1-3) embryos were transferred. The pregnancy, clinical pregnancy and twin pregnancy rates were 64.2%, 57.7% and 19.7%, respectively. In conclusion, given the high efficacy and safety of the GnRH-antagonist protocol triggered with a GnRH agonist, the monitoring of oestradiol concentrations is not necessary. Ultrasound monitoring is enough for an adequate follow up of the stimulation cycle in oocyte donors. |
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Authors:
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J C Castillo; M Dolz; J Moreno; L Gijón; R Ferrer; E Ferrero; F Bonilla-Musoles |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-20 |
Journal Detail:
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Title: Reproductive biomedicine online Volume: - ISSN: 1472-6491 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Clínica Fiv Valencia, Calle Santa Rosa 12, 46021 Valencia, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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