Document Detail


Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses.
MedLine Citation:
PMID:  21352854     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Traditionally, expression of toll-like receptors (TLRs) has been associated with innate immune cells in particular professional antigen presenting cells and natural killer cells. This led to the concept that the adjuvant effects of ligation of TLR in a host occur mainly in innate immune cells. However, this concept has been challenged by recent studies including ours demonstrating that T cells express appreciated levels of different TLRs, which can serve as costimulatory co-receptors during polyclonal and antigen-specific stimulation of T cells. Because T cells express low levels of TLRs as compared to innate immune cells, increasing the expression levels of TLRs in T cells can significantly maximize their responses to the costimulatory effects of TLR ligation. This review article focuses on the potential role of TLR expression in T cells in their responses to vaccination regimen containing TLR agonists and how it can be modulated to optimize anti-tumor immunity.
Authors:
Mohamed Labib Salem
Related Documents :
21464084 - Plasmodium falciparum-infected erythrocytes and beta-hematin induce partial maturation ...
21388924 - How does it act when soluble? critical evaluation of mechanism of galectin-1 induced t-...
21526214 - Rosmarinic acid, active component of dansam-eum attenuates ototoxicity of cochlear hair...
9523224 - Biology of chronic myelogenous leukemia.
22459704 - Biological properties and regulation of il-10 related cytokines and their contribution ...
9326744 - Substance p as an immune modulator of anxiety.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-22
Journal Detail:
Title:  Immunology letters     Volume:  -     ISSN:  1879-0542     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Immunology and Biotechnology Unit, Department of Zoology, Faculty of Science, Tanta University, Egypt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Generation of a Model of L-DOPA-Induced Dyskinesia in Two Different Mouse Strains.
Next Document:  The detection of rinderpest virus RNA extracted from a rapid chromatographic strip-test by RT-PCR.