Document Detail


Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis.
MedLine Citation:
PMID:  19442309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Acute pancreatitis (AP) is usually a mild and self-limiting disease, but some patients develop a severe form that is associated with high mortality. In AP, local inflammation is followed first by the systemic inflammatory response syndrome and then by the compensatory anti-inflammatory response syndrome, which is defined by low human leukocyte antigen (HLA)-DR expression on monocytes, increased concentration of the anti-inflammatory cytokine IL-10, and decreased monocyte function. Our aim was to measure the expression of triggering receptor expressed on myeloid cells (TREM)-1 (a proposed marker of infection or inflammation) and HLA-DR on monocytes, and the serum concentrations of IL-6 (a proinflammatory cytokine) and IL-10 in patients with AP to determine whether these markers can identify patients at high risk of developing severe AP or infection. METHODS: Fifty healthy volunteers, 18 patients with mild AP, and 11 patients with severe AP were included in this study. Samples were taken at admission and one and three days later. TREM-1 and HLA-DR expression was evaluated by flow cytometry, and soluble TREM-1, IL-6 and IL-10 concentrations were measured by ELISA. RESULTS: TREM-1 expression was higher in patients with AP than in healthy volunteers, but there was no difference between patients with mild and severe AP. TREM-1 expression was not associated with mortality or with the presence of infection. Soluble TREM-1 concentration in serum was higher in non-survivors than in survivors. HLA-DR expression was lower and IL-6 concentration higher in patients with severe AP and in infected patients. CONCLUSIONS: Increased TREM-1 expression was associated with the presence of inflammation but not infection in AP. In patients with AP, low HLA-DR expression and high IL-6 concentration could predict severity and infection in samples taken shortly after admission.
Authors:
Eduardo Ferat-Osorio; Isabel Wong-Baeza; Noemí Esquivel-Callejas; Silvia Figueroa-Figueroa; Andrés Duarte-Rojo; Gilberto Guzmán-Valdivia-Gómez; Heriberto Rodea-Rosas; Rubén Torres-González; Patricio Sánchez-Fernández; Lourdes Arriaga-Pizano; Constantino López-Macías; Guillermo Robles-Díaz; Armando Isibasi
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-05-14
Journal Detail:
Title:  Critical care (London, England)     Volume:  13     ISSN:  1466-609X     ISO Abbreviation:  Crit Care     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9801902     Medline TA:  Crit Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  R69     Citation Subset:  IM    
Affiliation:
Medical Research Unit on Immunochemistry, Specialties Hospital, National Medical Centre Siglo XXI, Mexican Institute for Social Security, Mexico City, Mexico. eduardoferat@prodigy.net.mx
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biological Markers / metabolism
Case-Control Studies
Female
HLA-DR Antigens / metabolism*
Humans
Infection / metabolism
Interleukin-10 / blood*
Interleukin-6 / blood*
Male
Membrane Glycoproteins / metabolism*
Middle Aged
Monocytes / metabolism*
Pancreatitis / diagnosis*,  metabolism
Receptors, Immunologic / metabolism*
Severity of Illness Index
Survival Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/HLA-DR Antigens; 0/Interleukin-6; 0/Membrane Glycoproteins; 0/Receptors, Immunologic; 0/TREM1 protein, human; 130068-27-8/Interleukin-10
Comments/Corrections
Comment In:
Crit Care. 2009;13(3):152   [PMID:  19519945 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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