| Triggering ovulation with gonadotropin-releasing hormone agonist in in vitro fertilization patients with polycystic ovaries does not cause ovarian hyperstimulation syndrome despite very high estradiol levels. | |
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MedLine Citation:
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PMID: 19200978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether inducing ovulation with a GnRH agonist in patients with polycystic ovaries (PCO) would permit oocyte retrieval without the burden or risk of cancellation, coasting, or ovarian hyperstimulation syndrome (OHSS), thus maintaining pregnancy rates by allowing embryo cryopreservation for transfer in a subsequent cycle. DESIGN: Retrospective observational study. SETTING: Private institution. PATIENT(S): Forty-two women who had previously experienced a controlled ovarian hyperstimulation (COH)/IVF cycle that had to be cancelled because of an elevated risk of OHSS. INTERVENTION(S): Forty-two PCO patients with a previous cancelled IVF cycle were assigned to a second controlled ovarian stimulation with recombinant FSH (75-150 IU/day) + GnRH antagonist (0.25 mg/day). Embryos were cryopreserved and transferred in a later cycle. MAIN OUTCOME MEASURE(S): OHSS, oocyte retrieval, and pregnancy rates. RESULT(S): In the first COH, the cycle had to be cancelled to avoid OHSS because E(2) serum levels were above safety levels (4809.6 +/- 2947.7). However, in the second cycle (ovulation triggered with a GnRH agonist) and independent of E(2) serum levels (4518.5 +/- 2118.85), all PCO patients eventually completed oocyte retrieval and frozen ET. With regard to pregnancy rates, 33% of patients receiving a transfer of a previously frozen embryo were successful. No patient developed OHSS. CONCLUSION(S): Triggering ovulation with a GnRH agonist followed by embryo cryopreservation allows PCO patients to complete a COH/IVF cycle with no cycle cancellation, coasting, or OHSS and, finally, to attain good pregnancy rates. |
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Authors:
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Maria A Manzanares; Jose Lui G?mez-Palomares; Elisabetta Ricciarelli; Eleuterio R Hern?ndez |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-02-06 |
Journal Detail:
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Title: Fertility and sterility Volume: 93 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1215-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Clinica FivMadrid, Juan Alvarez de Mendizabal, 28008 Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Estradiol / biosynthesis, blood* Female Fertilization in Vitro / adverse effects, methods Follicle Stimulating Hormone / adverse effects, pharmacology, therapeutic use Gonadotropin-Releasing Hormone / administration & dosage, agonists*, analogs & derivatives, blood* Humans Ovarian Hyperstimulation Syndrome / blood*, chemically induced Ovulation Induction* / methods Polycystic Ovary Syndrome / blood*, drug therapy Pregnancy Recombinant Proteins / adverse effects, pharmacology, therapeutic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 120287-85-6/cetrorelix; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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