Document Detail

Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone.
MedLine Citation:
PMID:  17445806     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of different human chorionic gonadotropin (hCG) doses on the ongoing pregnancy rates in patients with polycystic ovary syndrome (PCOS). DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary university referral center. PATIENT(S): Eighty PCOS patients. INTERVENTION(S): Patients were randomized to receive 10,000 IU (n = 28), 5000 IU (n = 26), or 2500 IU (n = 26) of hCG for triggering final oocyte maturation as soon as >or=3 or more follicles of 17 mm or larger were present at ultrasound. Patients were stimulated with recombinant follicle stimulating hormone (FSH) and daily gonadotropin-releasing hormone (GnRH) antagonist, starting on day 6 of stimulation. MAIN OUTCOME MEASURE(S): Ongoing pregnancy, fertilization rates. RESULT(S): The median fertilization rates were 52.8%, 65.4%, and 55.6% after administration of 10,000 IU, 5000 IU and 2500 IU, respectively. The ongoing pregnancy rates per PCOS patient receiving hCG were 26.9% (7 of 26), 30.8% (8 of 26) and 34.8% (8 of 23), respectively. CONCLUSION(S): A decrease in the dose of hCG used to trigger final oocyte maturation does not appear to affect adversely the probability of pregnancy in PCOS patients treated by IVF using GnRH antagonists and recombinant FSH, and further testing in future larger-scale trials is recommended.
Efstratios M Kolibianakis; Evangelos G Papanikolaou; Herman Tournaye; Michel Camus; Andre C Van Steirteghem; Paul Devroey
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-04-18
Journal Detail:
Title:  Fertility and sterility     Volume:  88     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-09     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1382-8     Citation Subset:  IM    
Centre for Reproductive Medicine, Vrije Universiteit Brussel, Brussels, Belgium.
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MeSH Terms
Chorionic Gonadotropin / administration & dosage*
Dose-Response Relationship, Drug
Follicle Stimulating Hormone, Human / pharmacology,  therapeutic use*
Gonadotropin-Releasing Hormone / antagonists & inhibitors*,  physiology
Oocytes / drug effects,  growth & development*
Pilot Projects
Polycystic Ovary Syndrome / drug therapy*,  physiopathology
Pregnancy Rate
Prospective Studies
Recombinant Proteins / pharmacology,  therapeutic use
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Follicle Stimulating Hormone, Human; 0/Recombinant Proteins; 33515-09-2/Gonadotropin-Releasing Hormone

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