Document Detail


Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.
MedLine Citation:
PMID:  20083005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We are testing the hypothesis that exercise is neuroprotective in animal models of the dopamine (DA) deficiency in Parkinson's disease. Our studies include mice or rats provided access to a running wheel and subsequently treated with MPTP (mice) or 6-hydroxydopamine (rats) and monkeys provided access to a treadmill and subsequently treated with MPTP. Typically, the exercise occurs for 3 months prior to the toxin treatment and often for 1-2 months thereafter. Our findings indicate that exercise reduces the behavioral impairments elicited by the dopaminergic neurotoxins as well as the loss of DA neurons as assessed by PET imaging and biochemical or histochemical assessment of tissue samples. Our studies are focused on one of several possible explanations for the beneficial effects of exercise: an exercise-induced increase in the expression of neurotrophic factors, particularly GDNF. Our observations indicate that GDNF can reduce the vulnerability of DA neurons, in part due to the activation of key intracellular cascades. We also find that mild cellular stress itself can provide protection against more intensive stress, a form of preconditioning. We conclude that dopamine neurons have the capacity to respond to intracellular and extracellular signals by triggering endogenous neuroprotective mechanisms. This raises the possibility that some individuals with Parkinson's disease suffer from a reduction of these neuroprotective mechanisms, and that treatments that boost these mechanisms - including exercise - may provide therapeutic benefit.
Authors:
Michael J Zigmond; Judy L Cameron; Rehana K Leak; Karoly Mirnics; Vivienne A Russell; Richard J Smeyne; Amanda D Smith
Related Documents :
15199375 - Hippocampal brain-derived neurotrophic factor expression following treatment with rebox...
24063915 - Abnormal heart rate recovery on exercise in ankylosing spondylitis.
24323375 - Heart rate variability in stroke patients submitted to an acute bout of aerobic exercise.
23369425 - Eccentric training in chronic heart failure: feasibility and functional effects. result...
9562365 - Effect of oral creatine ingestion on parameters of the work rate-time relationship and ...
3070015 - Psychophysiological reactivity of migraine sufferers in conditions of stress and relaxa...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  15 Suppl 3     ISSN:  1873-5126     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-03-31     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  S42-5     Citation Subset:  IM    
Affiliation:
Pittsburgh Institute for Neurodegenerative Disease, University of Pittsburgh, Pittsburgh, PA 15260, USA. zigmond@pitt.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Disease Models, Animal
Dopamine / deficiency*
Glial Cell Line-Derived Neurotrophic Factor / metabolism
Humans
Mice
Neurons / metabolism
Oxidopamine
Parkinson Disease, Secondary / chemically induced,  metabolism*,  rehabilitation*
Physical Conditioning, Animal / methods*
Rats
Grant Support
ID/Acronym/Agency:
AG021494/AG/NIA NIH HHS; DA018087/DA/NIDA NIH HHS; MH067234/MH/NIMH NIH HHS; NS045906/NS/NINDS NIH HHS; NS053471/NS/NINDS NIH HHS; NS19608/NS/NINDS NIH HHS; NS45698/NS/NINDS NIH HHS; R01 NS070825/NS/NINDS NIH HHS; TW008040/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Glial Cell Line-Derived Neurotrophic Factor; 1199-18-4/Oxidopamine; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Scales to evaluate psychosis in Parkinson's disease.
Next Document:  Exercise programs improve mobility and balance in people with Parkinson's disease.