| Triggering Receptor Expressed on Myeloid Cells Type 1 as a Potential Therapeutic Target in Sepsis. | |
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MedLine Citation:
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PMID: 22156803 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Excessive and unregulated inflammation contributes to multiorgan failure and death in sepsis. Triggering receptor expressed on myeloid cells type 1(TREM-1) is expressed on neutrophils and monocytes and is upregulated in the presence of bacterial pathogens. Engagement of TREM-1 results in increased expression of proinflammatory chemokines and cytokines and amplifies the inflammatory response. In this article, we will review the structure and signaling pathway of TREM-1 and review the role of TREM-1 and soluble TREM-1 in the inflammatory response during sepsis. Based on these studies, modulation of the TREM-1 signaling pathway has been suggested as a potential therapeutic strategy for the treatment of sepsis, to dampen the inflammatory response without interrupting the ability of the host to clear pathogens. This basic science research may someday lead to other treatments for sepsis and other diseases. |
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Authors:
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Steven J Palazzo; Terri Simpson; Lynn M Schnapp |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Dimensions of critical care nursing : DCCN Volume: 31 ISSN: 1538-8646 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211489 Medline TA: Dimens Crit Care Nurs Country: - |
Other Details:
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Languages: ENG Pagination: 1-6 Citation Subset: - |
Affiliation:
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Steven J. Palazzo, PhD, RN, CCRN, is a recent graduate from the University of Washington School of Nursing, Seattle. His research is focused on the utility of biomarkers for diagnosing ventilator-associated pneumonia. He is an assistant clinical professor at the College of Nursing, Seattle University and has 8 years' experience as a medical/cardiac critical care nurse at Harborview Medical Center. Terri Simpson, PhD, RN, is an associate professor of nursing in the Department of Biobehavioral Nursing and Health Systems at the University of Washington, Seattle. Lynn M. Schnapp, MD, is a professor in the Division of Pulmonary and Critical Care Medicine at the University of Washington, Seattle. |
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