Document Detail


Triggered C-reactive protein (CRP) concentrations and the CRP gene -717A>G polymorphism in acute stroke or transient ischemic attack.
MedLine Citation:
PMID:  17355554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C-reactive protein (CRP) increases following an acute stroke/transient ischemic attack (TIA), but the increment level varies among patients. We analyzed CRP concentrations during an acute stroke/TIA in relation to the CRP gene -717A>G polymorphism. Six months following an acute ischemic stroke/TIA, basal concentrations of CRP were measured in 507 controls and 219 patients and were found to be unassociated with the CRP -717A>G polymorphism. However, during the acute phase of stroke/TIA, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 +/- 1.59 vs. 1.73 +/- 1.69 mg/l, P = 0.027). In addition, significant 3.22-fold increments in CRP concentrations was noted in individuals carrying the -717G allele when comparing the acute phase with the basal state of each patient and averaging the results. CRP -717A>G polymorphism is associated with triggered CRP concentrations during acute stroke/TIA. These findings might shed more light on the mechanisms of CRP elevation in acute ischemic stroke/TIA.
Authors:
E Ben-Assayag; S Shenhar-Tsarfaty; I Bova; S Berliner; L Shopin; H Peretz; S Usher; I Shapira; N M Bornstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  14     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-05-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  315-20     Citation Subset:  IM    
Affiliation:
Department of Neurology, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
C-Reactive Protein / analysis,  genetics*,  metabolism*
DNA Mutational Analysis
Female
Gene Frequency
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Ischemic Attack, Transient / blood,  genetics*,  physiopathology
Male
Middle Aged
Mutation / genetics
Polymorphism, Genetic / genetics*
Stroke / blood,  genetics*,  physiopathology
Up-Regulation / genetics
Chemical
Reg. No./Substance:
0/Genetic Markers; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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