Document Detail

Trigemino-cervical response in patients with amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  15861856     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The trigemino-cervical response (TCR) was investigated in the patients with amyotrophic lateral sclerosis (ALS) to evaluate its effect for disclosing the bulbar involvement in this disorder. METHODS: We studied 100 normal subjects and 45 patients with ALS. In all normal subjects, stimulation of the infraorbital nerve on one side produced bilateral short latency waves, which consisted of a positive/negative wave described with the mean peak latency (P20/N30). The mean square root of the ratio between the amplitude of P20/N30 and the mean rectified surface EMG activity preceding the stimulus was described by A value. RESULTS: The latency of P20 in controls was 18.5 +/- 1.4 ms, N30 was 28.8 +/- 2.8 ms, and the A value was 1.6 +/- 0.5, respectively. In ALS patients, twelve showed absent, seventeen were delayed in the latencies, six were above normal asymmetry on two sides, and ten showed normal. The latency of P20 in ALS patients was 22.9 +/- 9.4 ms, N30 was 33.7 +/- 11.2 ms, and the A value was 1.5 +/- 0.8, respectively. The parameters of the latencies of TCR between ALS patients and the normal controls were statistically different (P < 0.05). CONCLUSIONS: TCR can be reliably measured in all normal subjects and help in disclosing lower brainstem lesions in ALS patients, even without bulbar symptoms.
Y Xu; D Fan; J Zhang; J Zheng; S Zhang; D Kang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Electromyography and clinical neurophysiology     Volume:  45     ISSN:  0301-150X     ISO Abbreviation:  Electromyogr Clin Neurophysiol     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0327533     Medline TA:  Electromyogr Clin Neurophysiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Department of Neurology, Peking University Third Hospital, Beijing 100083, China.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications,  diagnosis*,  physiopathology*
Brain Stem / pathology*
Case-Control Studies
Diagnosis, Differential
Electric Stimulation
Functional Laterality
Middle Aged
Neural Conduction
Reaction Time
Reproducibility of Results
Trigeminal Nerve / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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