| Trientine and renin-angiotensin system blockade ameliorate progression of glomerular morphology in hypertensive experimental diabetic nephropathy. | |
| | |
MedLine Citation:
|
PMID: 22029676 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
A comparison of the efficacy of the copper chelator, trientine, with combined renin angiotensin system (RAS) blockade on the progression of glomerular pathology in the diabetic (mREN-2)27 rat is reported. Animals were treated for 2 months with trientine, combined RAS blockers, combined trientine plus RAS blockers or none. Treatments began after inducing diabetes with streptozotocin. Physiological data were recorded monthly and light microscopic glomerular features were scored. Plasma allantoin and both plasma and renal protein carbonyls were measured as markers of oxidative stress. Trientine and RAS blockade decreased proteinuria and albuminuria and prevented an increase in creatinine clearance and kidney weight. Both reduced the diabetes-related glomerular features of mesangiolysis and glomerular segmental hypocellularity and trientine prevented severe tuft-to-capsule adhesion and reduced tubularization. Hypertension-related severe mesangial matrix expansion and global hypercellularity were increased by both treatments, which may reflect repair of mesangiolysis. Trientine reduced plasma but not renal protein carbonyls or plasma allantoin. In this model, trientine prevented the development of many diabetes-specific features similarly to RAS blockade. Amelioration of oxidative stress and features commonly observed in human diabetic nephropathy (DN), support a diabetes-related defect in copper (Cu) metabolism. The addition of Cu(II) chelation may improve current DN therapy. |
| | |
Authors:
|
Leire Moya-Olano; Helen Marie Milne; Jillian Margaret Robinson; Jonathan Vernon Hill; Christopher Miles Frampton; Helen Frances Abbott; Rufus Turner; Anthony James Kettle; Zoltán Huba Endre |
Related Documents
:
|
14228226 - A comparison of the oral and intravenous glucose tolerance tests in non-diabetic, possi... 8591826 - Metabolic characteristics of african descendants: a comparative study of african-americ... 7085466 - Effect of diet on the oral glucose tolerance test in the horse. 847746 - Plasma c-peptide response to oral glucose in low insulin responders, subdiabetic, and d... 19504086 - Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pa... 6597316 - Prostaglandin e2 and parathyroid hormone: comparisons of their actions on the rabbit pr... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pathology international Volume: 61 ISSN: 1440-1827 ISO Abbreviation: Pathol. Int. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9431380 Medline TA: Pathol Int Country: Australia |
Other Details:
|
Languages: eng Pagination: 652-61 Citation Subset: IM |
Copyright Information:
|
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Departments of Medicine Pathology, University of Otago-Christchurch, Christchurch, New Zealand Department of Nephrology and Hypertension, University of Cincinnati College of Medicine, Cincinnati, Ohio Division of Nephrology, University of Colorado, Denver, Colorado Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA Prince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In situ expression of the CCL20-CCR6 axis in lymphocyte-rich gastric cancer and its potential role i...
Next Document: Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma.