Document Detail

Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells by activation of the p38 MAPK pathway.
MedLine Citation:
PMID:  19959910     Owner:  NLM     Status:  MEDLINE    
We have reported that treatment with trientine, Cu-chelating agent, inhibits tumor growth in a murine transplantation model using fibrosarcoma and induces apoptosis in tumor cells in vivo and in vitro. When fibrosarcoma cells were treated with 10 mM trientine, the activities of p38 MAPK in treated cells were approximately 3-4 times higher than those in untreated cells. Proportions of cells in which apoptosis was induced by trientine increased in an incubation time-dependent manner from days 2 to 6. The proportions of apoptotic cells in the cells treated with trientine and SB203580, an inhibitor of p38 MAPK, were approximately 50% in those of cells treated with trientine alone. The present results showed that the p38 MAPK pathway may play an important role in induction of apoptosis in fibrosarcoma cells by trientine.
Shingo KADOWAKI; Daiji ENDOH; Toyo OKUI; Masanobu HAYASHI
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  71     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-04     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1541-4     Citation Subset:  IM    
Department of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
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MeSH Terms
Apoptosis / drug effects*
Cell Line, Tumor
Chelating Agents / pharmacology*
Copper / metabolism
Enzyme Activation
Fibrosarcoma / enzymology*
Imidazoles / pharmacology
Pyridines / pharmacology
Signal Transduction
Triethylenetetramine / pharmacology*
p38 Mitogen-Activated Protein Kinases / metabolism*
Reg. No./Substance:
0/Chelating Agents; 0/Imidazoles; 0/Pyridines; 0/SB 203580; 112-24-3/Triethylenetetramine; 7440-50-8/Copper; EC Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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