| Tricyclic antidepressants in the treatment of peptic ulcer disease. | |
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MedLine Citation:
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PMID: 7059255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Doxepin hydrochloride was given to 12 patients with duodenal ulcer and one patient with an anastomotic ulcer. The dose of doxepin hydrochloride was 100 mg at bedtime, except in patients receiving hemodialysis, where only 50 mg at bedtime was given. Eight patients, including the four receiving hemodialysis, has not responded to treatment after eight weeks of cimetidine and/or antacid therapy. All patients (except one where a minor erosion was left in the duodenum) responded, and healing of the ulcer was demonstrated by endoscopy after four to six weeks of treatment. In two patients the ulcer recurred in four to eight weeks after discontinuation of doxepin therapy; however, ulcers healed after four weeks when therapy was reintroduced. Five previously untreated patients with duodenal ulcer were also given the same treatment. Four healed six weeks after starting doxepin therapy. In one patient the dose of doxepin hydrochloride had to be raised to 150 mg for complete healing. |
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Authors:
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J C Mangla; M Pereira |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of internal medicine Volume: 142 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1982 Feb |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 273-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antidepressive Agents, Tricyclic / pharmacology Cimetidine / therapeutic use Doxepin / therapeutic use* Duodenal Ulcer / drug therapy Female Histamine Antagonists Humans Male Middle Aged Peptic Ulcer / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 0/Histamine Antagonists; 1668-19-5/Doxepin; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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