Document Detail

Tricyclic antidepressants in the treatment of peptic ulcer disease.
MedLine Citation:
PMID:  7059255     Owner:  NLM     Status:  MEDLINE    
Doxepin hydrochloride was given to 12 patients with duodenal ulcer and one patient with an anastomotic ulcer. The dose of doxepin hydrochloride was 100 mg at bedtime, except in patients receiving hemodialysis, where only 50 mg at bedtime was given. Eight patients, including the four receiving hemodialysis, has not responded to treatment after eight weeks of cimetidine and/or antacid therapy. All patients (except one where a minor erosion was left in the duodenum) responded, and healing of the ulcer was demonstrated by endoscopy after four to six weeks of treatment. In two patients the ulcer recurred in four to eight weeks after discontinuation of doxepin therapy; however, ulcers healed after four weeks when therapy was reintroduced. Five previously untreated patients with duodenal ulcer were also given the same treatment. Four healed six weeks after starting doxepin therapy. In one patient the dose of doxepin hydrochloride had to be raised to 150 mg for complete healing.
J C Mangla; M Pereira
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  142     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-5     Citation Subset:  AIM; IM    
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MeSH Terms
Antidepressive Agents, Tricyclic / pharmacology
Cimetidine / therapeutic use
Doxepin / therapeutic use*
Duodenal Ulcer / drug therapy
Histamine Antagonists
Middle Aged
Peptic Ulcer / drug therapy*
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 0/Histamine Antagonists; 1668-19-5/Doxepin; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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