| Tricyclic antidepressants and cardiac conduction: changes in ventricular automaticity. | |
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MedLine Citation:
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PMID: 824144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ventricular dysrhythmias result from changes in the automaticity or the conduction properties of the specialized conduction system. Tricyclic antidepressants have been reported to cause ventricular dysrhythmias in humans and experimental animals. Consequently, it seemed to interest to determine whether these substances influence ventricular automaticity. Ventricular rhythm was produced in anesthetized dogs by blocking atrioventricular conduction. Low doses of imipramine, amitriptyline and nortriptyline resulted in small but significant increases in automaticity. Relatively high doses of these agents suppressed automaticity markedly. These changes could play a role in the development of dysrhythmias. |
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Authors:
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T Baum; J R Peters; F Butz; D R Much |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 39 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1976 Oct |
Date Detail:
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Created Date: 1977-01-03 Completed Date: 1977-01-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 323-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amitriptyline
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pharmacology Animals Antidepressive Agents, Tricyclic / pharmacology* Arrhythmias, Cardiac / chemically induced Blood Pressure / drug effects Dogs Female Heart Atria / drug effects Heart Conduction System / drug effects* Heart Rate / drug effects Heart Ventricles / drug effects Imipramine / pharmacology Male Nitroglycerin / pharmacology Nortriptyline / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 50-48-6/Amitriptyline; 50-49-7/Imipramine; 55-63-0/Nitroglycerin; 72-69-5/Nortriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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