Document Detail


Tricuspid regurgitation and right ventricular function after mitral valve surgery with or without concomitant tricuspid valve procedure.
MedLine Citation:
PMID:  23010580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To study the effect of mitral valve repair with or without concomitant tricuspid valve repair on functional tricuspid regurgitation and right ventricular function.
METHODS: From 2001 to 2007, 1833 patients with degenerative mitral valve disease, a structurally normal tricuspid valve, and no coronary artery disease underwent mitral valve repair, and 67 underwent concomitant tricuspid valve repair. Right ventricular function (myocardial performance index and tricuspid annular plane systolic excursion) was measured before and after surgery using transthoracic echocardiography for randomly selected patients with tricuspid regurgitation grade 0, 1+, and 2+ (100 patients for each grade) and 93 with grade 3+/4+, 393 patients in total.
RESULTS: In patients with mild (<3+) preoperative tricuspid regurgitation, mitral valve repair alone was associated with reduced tricuspid regurgitation and mild worsening of right ventricular function. Tricuspid regurgitation of 2+ or greater developed in fewer than 20%, and right ventricular function had improved, but not to preoperative levels, at 3 years. In patients with severe (3+/4+) preoperative tricuspid regurgitation, mitral valve repair alone reduced tricuspid regurgitation and improved right ventricular function; however, tricuspid regurgitation of 2+ or greater returned and right ventricular function worsened toward preoperative levels within 3 years. Concomitant tricuspid valve repair effectively eliminated severe tricuspid regurgitation and improved right ventricular function. Also, over time, tricuspid regurgitation did not return and right ventricular function continued to improve to levels comparable to that of patients with lower grades of preoperative tricuspid regurgitation.
CONCLUSIONS: In patients with mitral valve disease and severe tricuspid regurgitation, mitral valve repair alone was associated with improved tricuspid regurgitation and right ventricular function. However, the improvements were incomplete and temporary. In contrast, concomitant tricuspid valve repair effectively and durably eliminated severe tricuspid regurgitation and improved right ventricular function toward normal, supporting an aggressive approach to important functional tricuspid regurgitation.
Authors:
Ravi R Desai; Lina Maria Vargas Abello; Allan L Klein; Thomas H Marwick; Richard A Krasuski; Ying Ye; Edward R Nowicki; Jeevanantham Rajeswaran; Eugene H Blackstone; Gösta B Pettersson
Publication Detail:
Type:  Journal Article; Observational Study; Research Support, Non-U.S. Gov't     Date:  2012-09-22
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  146     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-16     Completed Date:  2014-01-07     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1126-1132.e10     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cardiac Surgical Procedures* / adverse effects
Chi-Square Distribution
Female
Humans
Linear Models
Logistic Models
Male
Markov Chains
Mitral Valve Insufficiency / complications,  diagnosis*,  physiopathology,  surgery*
Monte Carlo Method
Multivariate Analysis
Recovery of Function
Severity of Illness Index
Time Factors
Treatment Outcome
Tricuspid Valve Insufficiency / complications,  diagnosis,  physiopathology,  surgery*
Ventricular Dysfunction, Right / diagnosis,  etiology,  physiopathology*
Ventricular Function, Right*
Grant Support
ID/Acronym/Agency:
R01 HL103552/HL/NHLBI NIH HHS; UL1 TR000439/TR/NCATS NIH HHS
Comments/Corrections

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