Document Detail

Tricuspid annular systolic velocity predicts maximal oxygen consumption during exercise in adult patients with repaired tetralogy of Fallot.
MedLine Citation:
PMID:  17904816     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many patients with repaired tetralogy of Fallot (TOF) have clinically important pulmonary regurgitation that can eventually lead to right ventricular (RV) dilatation and dysfunction and associated morbidity and mortality. Unfortunately, standard echocardiographic techniques to evaluate RV size and function can be inaccurate. Newer Doppler modalities such as Doppler tissue imaging (DTI) can detect subtle changes in myocardial velocities and may better identify subclinical RV dysfunction in these patients. METHODS: A total of 25 patients with repaired TOF prospectively underwent complete echocardiographic assessment (including DTI) of the RV and cardiopulmonary stress testing to evaluate exercise capacity. Echocardiographic variables were compared with age- and sex-matched control subjects. RESULTS: Patients with repaired TOF had significantly lower RV DTI indices compared with control subjects. In patients with repaired TOF, RV peak systolic velocity had a significant correlation with maximal oxygen consumption during exercise (r = 0.80, P < .001) and was the only independent predictor of maximal oxygen consumption on multivariate analysis (r = 0.80, P < .001). CONCLUSION: DTI identifies abnormalities of RV systolic and diastolic function in patients with repaired TOF. Importantly, RV systolic velocity is predictive of exercise capacity in these patients.
Omid Salehian; Ian G Burwash; Kwan L Chan; Luc M Beauchesne
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-09-29
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  21     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-6     Citation Subset:  IM    
McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Echocardiography, Doppler / methods*
Exercise Test*
Oxygen Consumption*
Reproducibility of Results
Sensitivity and Specificity
Tetralogy of Fallot / physiopathology,  surgery*,  ultrasonography*
Treatment Outcome
Tricuspid Valve / physiopathology,  ultrasonography*
Tricuspid Valve Insufficiency / physiopathology,  ultrasonography*
Ventricular Dysfunction, Right / physiopathology,  ultrasonography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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