| Tricomponent Catalytic α,α-Difluorination of Acid Chlorides. | |
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MedLine Citation:
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PMID: 21875036 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The selective α,α-difluorination of carbonyl compounds remains a challenge in modern organic synthesis; current methods often incorporate stepwise processes and/or harsh conditions, providing unsatisfactory mixtures of mono- and difluorinated products. In this communication, a practical, mild, and one-pot method for the selective α,α-difluorination of readily available acid chlorides is reported in which three separate catalysts act synergistically to form products in outstanding selectivity and fair to excellent yields. |
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Authors:
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Steven Bloom; Michael T Scerba; Jeremy Erb; Thomas Lectka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-29 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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