Document Detail

Triclosan release from coated polyglycolide threads.
MedLine Citation:
PMID:  16374771     Owner:  NLM     Status:  MEDLINE    
Copolymerization of lactide, epsilon-caprolactone, and trimethylene carbonate is performed. The synthesis is focused on obtaining materials with adequate properties for application as a suture coating that could contain an antimicrobial agent like triclosan. An amorphous character, a low glass transition temperature, a moderate susceptibility to degradation, and a hydrophobic nature are the conditions required for the optimal behavior of this coating. These properties can be attained with a copolymer of composition 10:60:30. Triclosan is added to the surface of polyglycolide threads and its release is studied in different media with high-performance liquid chromatography. The influence of the temperature, the diameter of the thread, the initial concentration of the antibacterial agent, and the applied procedure on the incorporation of triclosan is also evaluated. A total release of triclosan is attained after a few days of exposure to a Dulbecco's based medium, whereas equilibrium concentrations are reached when a Sörensen hydrophilic medium is used. Partition and diffusion coefficients are also estimated.
Raül Zurita; Jordi Puiggalí; Alfonso Rodríguez-Galán
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Macromolecular bioscience     Volume:  6     ISSN:  1616-5187     ISO Abbreviation:  Macromol Biosci     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-28     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  58-69     Citation Subset:  IM    
Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, 08028 Barcelona, Spain.
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MeSH Terms
Absorbable Implants*
Anti-Infective Agents, Local / chemistry*
Coated Materials, Biocompatible / chemistry*
Dioxanes / chemistry
Materials Testing
Microscopy, Electron, Scanning
Polyesters / chemistry
Polyglycolic Acid / chemistry*
Surgical Wound Infection / prevention & control*
Triclosan / chemistry*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Coated Materials, Biocompatible; 0/Dioxanes; 0/Polyesters; 0/trimethylene carbonate; 26009-03-0/Polyglycolic Acid; 3380-34-5/Triclosan; 70524-20-8/lactide-caprolactone copolymer

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