Document Detail

Triclosan in individual human milk samples from Australia.
MedLine Citation:
PMID:  22000243     Owner:  NLM     Status:  Publisher    
Triclosan is a chlorinated phenol ether that has been in widespread use as a broad-spectrum antibacterial agent for four decades. When compared to the limited international data available on human body burden of triclosan, results from a pooled blood study suggested that triclosan concentrations in Australia were a factor two higher than observed in Sweden. This study determined triclosan levels in individual human milk samples (n=151) collected between 2002 and 2005 from primiparous Australian mothers. It provided the first report of population triclosan levels and individual variation in Australia and gave a measure of infant exposure via breast feeding. The distribution of triclosan concentration was positively skewed, with 7.2% of the samples below the LOQ, 66% with a concentration of less than or equal to 1.0ngg(-1)fresh weight and the remaining samples above 1ngg(-1) reaching a maximum concentration of 19ngg(-1)fresh weight. The mean and median triclosan concentrations were 1.3±2.7ngg(-1)f.w. and 0.26ngg(-1)f.w., respectively. The results of this study showed high variability in triclosan concentrations between individuals and no correlations with maternal age (p=0.094), maternal weight (p=0.971) or infant age at the time of sample collection (p=0.621). A large number of samples contained low or non-quantifiable concentrations of triclosan and so, in Australia, ubiquitous background exposure due to environmental sources is low. This means that body burden can be influenced by an individual's use of triclosan containing product. Given that triclosan containing product use is continuing, it is important that monitoring in both humans and the environment is continued and that triclosan containing products are adequately labeled so that an individual can choose to avoid exposure.
Leisa-Maree L Toms; Mats Allmyr; Jochen F Mueller; Margaretha Adolfsson-Erici; Michael McLachlan; John Murby; Fiona A Harden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-12
Journal Detail:
Title:  Chemosphere     Volume:  -     ISSN:  1879-1298     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, Australia; Medical Radiation Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
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