Document Detail


Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm.
MedLine Citation:
PMID:  20387099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To develop tooth-binding micelle formulations of triclosan for the prevention and treatment of dental caries.
METHODS: Alendronate (ALN) was conjugated to the chain termini of different Pluronic copolymers to confer tooth-binding ability to the micelles. Using 3 different formulation methods, Pluronics and ALN-modified Pluronics were used to prepare triclosan-loaded tooth-binding micelles. The formulation parameters were optimized for triclosan solubility, particle size, hydroxyapatite (HA) binding capability and in vitro drug release profile. The optimized formulation was tested on an in vitro biofilm model.
RESULTS: Direct dissolution was selected as the best formulation method. Triclosan-loaded tooth-binding micelles were able to inhibit initial biofilm growth of Streptococcus mutans UA159 by 6-log CFU/HA disc compared to the untreated control. These tooth-binding micelles were also able to reduce the viability of preformed biofilm by 4-log CFU/HA disc compared to the untreated control.
CONCLUSIONS: Triclosan-loaded tooth-binding micelle formulations have been successfully developed and optimized in this study. These micelle formulations demonstrated promising anti-cariogenic bacteria capabilities and may find applications in the prevention and treatment of dental caries.
Authors:
Fu Chen; Kelly C Rice; Xin-Ming Liu; Richard A Reinhardt; Kenneth W Bayles; Dong Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-13
Journal Detail:
Title:  Pharmaceutical research     Volume:  27     ISSN:  1573-904X     ISO Abbreviation:  Pharm. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2011-02-17     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2356-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biofilms*
Humans
Micelles*
Solubility
Triclosan / administration & dosage*,  classification
Grant Support
ID/Acronym/Agency:
R01 AI038901/AI/NIAID NIH HHS; R01 AR053325/AR/NIAMS NIH HHS; R01 AR053325/AR/NIAMS NIH HHS; R03 DE019179/DE/NIDCR NIH HHS; RR021937/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Micelles; 4NM5039Y5X/Triclosan
Comments/Corrections

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