| Trichotillomania: a case of response to valproic acid. | |
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MedLine Citation:
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PMID: 18928419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trichotillomania (TTM) is a commonly undiagnosed psychiatric illness with known medical complications whose symptoms interfere markedly with daily functioning. Studies regarding the pharmacological treatment of TTM in the adult or pediatric population are sparse, and there is a lack of consensus on drug treatment for TTM. The current trend is to use selective serotonin reuptake inhibitors (SSRIs) on the basis of the current hypothesis that TTM may be a part of the obsessive compulsive spectrum of disorders. However, attempts to substantiate the efficacy of SSRI use in TTM has produced conflicting results. There is increasing evidence that mood stabilizers decrease symptoms of TTM. We present the case of a 10-year-old girl whose lifelong hair-plucking symptoms showed remarkable sustained improvement in response to increased levels of valproic acid. This report, the first with valproic acid, indicates that this drug is potentially effective in significantly reducing symptoms of TTM in a sustained manner. This single case report calls for further investigation regarding the utility of valproic acid in the treatment of TTM. |
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Authors:
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Edore C Adewuya; William Zinser; Christopher Thomas |
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Publication Detail:
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Type: Case Reports; Letter |
Journal Detail:
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Title: Journal of child and adolescent psychopharmacology Volume: 18 ISSN: 1557-8992 ISO Abbreviation: J Child Adolesc Psychopharmacol Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105358 Medline TA: J Child Adolesc Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 533-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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administration & dosage,
therapeutic use* Antimanic Agents / administration & dosage, therapeutic use Child Dose-Response Relationship, Drug Female Follow-Up Studies Humans Trichotillomania / drug therapy*, physiopathology Valproic Acid / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Antimanic Agents; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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