| Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin. | |
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MedLine Citation:
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PMID: 6636168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H2O2, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin. |
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Authors:
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R Segal; I Milo-Goldzweig; A Z Joffe; B Yagen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology and applied pharmacology Volume: 70 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 343-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Darkness Dose-Response Relationship, Drug Drug Interactions Erythrocytes / drug effects, metabolism Free Radicals Hemolysis / drug effects* Lipid Peroxides / blood Male Rats Sesquiterpenes / toxicity* T-2 Toxin / toxicity* Time Factors Trichothecenes / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Lipid Peroxides; 0/Sesquiterpenes; 0/Trichothecenes; 21259-20-1/T-2 Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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