Document Detail


Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin.
MedLine Citation:
PMID:  6636168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H2O2, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.
Authors:
R Segal; I Milo-Goldzweig; A Z Joffe; B Yagen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  70     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  343-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Darkness
Dose-Response Relationship, Drug
Drug Interactions
Erythrocytes / drug effects,  metabolism
Free Radicals
Hemolysis / drug effects*
Lipid Peroxides / blood
Male
Rats
Sesquiterpenes / toxicity*
T-2 Toxin / toxicity*
Time Factors
Trichothecenes / toxicity*
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Lipid Peroxides; 0/Sesquiterpenes; 0/Trichothecenes; 21259-20-1/T-2 Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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